Upregulation of SIRT1 gene in gastric adenocarcinoma
| Autor: | Önder Özcan, Murat Polat, Selami Ilgaz Kayilioglu, Esin Sakalli Cetin, Mehmet Kaplan, Ahmet Korkut Belli, Özgür İlhan Çelik, Cem Çağrı Dönmez, Murat Kara |
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| Přispěvatelé: | MÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Özcan, Önder, Belli, Ahmet Korkut, Çetin, Esin Sakallı, Kara, Murat, Çelik, Özgur İlhan, Polat, Murat |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Gene Expression Gastric Adenocarcinoma Disease Adenocarcinoma Gastroenterology 03 medical and health sciences 0302 clinical medicine Sirtuin 1 Stomach Neoplasms Signet ring cell carcinoma Internal medicine Biomarkers Tumor Carcinoma medicine Humans SIRT1 Gene Pathological Aged Aged 80 and over business.industry Stomach Case-control study Cancer Middle Aged Prognosis medicine.disease digestive system diseases Up-Regulation 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Relative risk Female Original Article business Carcinoma Signet Ring Cell |
| Zdroj: | The Turkish Journal of Gastroenterology. 30:326-330 |
| ISSN: | 2148-5607 1300-4948 |
| DOI: | 10.5152/tjg.2019.18550 |
| Popis: | WOS: 000463369400003 PubMed ID: 30945643 Background/Aims: SIRT1 gene overexpression is reportedly associated with cancer development, via the triggering of DNA repair impairment, and cell proliferation. The study aimed to investigate SIRT1 expression in patients with gastric cancer and its correlations with the clinical and pathological characteristics of the disease. Materials and Methods: All patients (64 patients) who underwent gastric biopsy and were diagnosed with gastric adenocarcinoma and signet ring cell carcinoma between January 2011 and December 2013 were enrolled in the study, and patients with benign gastric biopsy were enrolled in the control group (34 patients). The previously prepared gastric tissues were collected from the pathology department, and SIRT1 gene expressions were evaluated in the gastric tissues of all study patients. Patients were subclassified according to their demographic, clinical, and pathologic features, and the patient and control groups were compared. Results: Sixty-four patients were included in the study (25 females and 39 males). The mean age of the patients was 66 +/- 1 (range: 3388) years. The SIRT1 gene 2' Average delta cycle threshold (CT) value was 0.102 in the control group, whereas it was 0.292 in the patients with gastric cancer (relative risk: 2.86; p=0.014). The SIRT1 gene was upregulated in all tumor stage subgroups except stage I, female patients, young patients ( |
| Databáze: | OpenAIRE |
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