Effects of adrenomedullin on adrenocorticotropic hormone (ACTH) release in pituitary cell cultures and on ACTH and oxytocin responses to shaker stress in conscious rat
| Autor: | Tatsuya Nishioka, Kozo Hashimoto, Tomoko Mimoto, Koichi Asaba, Toshihiro Takao |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System endocrine system Vasopressin medicine.medical_specialty Corticotropin-Releasing Hormone Vasopressins Pituitary-Adrenal System Adrenocorticotropic hormone Oxytocin Adrenomedullin Corticotropin-releasing hormone Adrenocorticotropic Hormone Anterior pituitary Stress Physiological Physical Stimulation Internal medicine medicine Animals Rats Wistar Molecular Biology Cells Cultured Dose-Response Relationship Drug Chemistry General Neuroscience Rats medicine.anatomical_structure Endocrinology Pituitary Gland Neurology (clinical) Corticotropic cell Peptides hormones hormone substitutes and hormone antagonists Developmental Biology Blood sampling medicine.drug |
| Zdroj: | Brain Research. 922:261-266 |
| ISSN: | 0006-8993 |
| Popis: | Adrenomedullin (AM) is a potent vasodilator peptide, which is initially isolated from tissue of human pheochromocytoma. In addition to the effect on cardiovascular system, previous studies suggest that AM plays some roles as a neuropeptide in the brain. In the present study, we examined the effect of AM on in vitro adrenocorticotropic hormone (ACTH) secretion stimulated by corticotropin-releasing hormone (CRH), vasopressin (VP) or oxytocin (OT) in cultured rat corticotrophs and on the response of plasma ACTH, corticosterone (B) and OT to shaker stress in vivo. In contrast to the previous report, basal or CRH (10(-9) M)-stimulated ACTH secretion was not affected by coincubation with AM. Either of VP (10(-8) M) or OT (10(-8) M) significantly increased ACTH secretion in cultured rat anterior pituitary cells (156.7+/-24.9 in basal incubation vs. 267.8+/-15.0 in VP-stimulation, P |
| Databáze: | OpenAIRE |
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