Effects of β-Sitosteryl Sulfate on the Properties of DPPC Liposomes
| Autor: | Masaaki Akamatsu, Teruhisa Kaneko, Chihiro Kaise, Avinash Bhadani, Kenichi Sakai, Ananda Kafle, Hideki Sakai |
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| Rok vydání: | 2018 |
| Předmět: |
Liposome
Dppc liposomes 1 2-Dipalmitoylphosphatidylcholine Membrane Fluidity General Chemical Engineering Sonication Multilamellar liposomes 02 engineering and technology General Medicine General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Sitosterols 0104 chemical sciences chemistry.chemical_compound chemistry Chemical engineering Liposomes Particle Particle size Sulfate Particle Size 0210 nano-technology Fluorescence anisotropy |
| Zdroj: | Journal of oleo science. 67(12) |
| ISSN: | 1347-3352 |
| Popis: | The effect of β-sitosteryl sulfate (PSO4) on the liposomal size, stability, fluidity, and dispersibility of DPPC liposomes prepared by vortex mixing, bath-sonication, and probe-sonication has been studied. PSO4 significantly decreases the particle size of the multilamellar liposomes (MLVs). The sizes of the vortexmixed and the bath-sonicated liposomes vary as a function of PSO4 concentration. On the other hand, PSO4 has only little effect on the particle sizes of probe sonicated liposomes. In some cases, the liposomal stability at higher PSO4 concentrations depends on the preparation method. PSO4 improves the dispersibility of the DPPC liposomes and enhances their hydration. It also increases the fluidity of the liposomes prepared by each method. Our results suggest that liposomes consisting of DPPC and PSO4 can be suitable as a cosmetic or pharmaceutical ingredient for the effective delivery of the active components into the body. |
| Databáze: | OpenAIRE |
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