Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers
Autor: | Iris Udasin, Jessica A. Cervelli, Jared Radbel, Sabiha Hussain, Jag Sunderram, Vasanthi R. Sunil, Jeffrey D. Laskin, Debra L. Laskin, Malik Deen, Howard M. Kipen, Robert Laumbach, Kinal N. Vayas |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty Sarcoidosis injury Health Toxicology and Mutagenesis lcsh:Medicine complex mixtures Article 03 medical and health sciences Cytokeratin 0302 clinical medicine Fibrosis Occupational Exposure Pulmonary fibrosis Biopsy medicine Humans fibrotic sarcoid Lymph node Pathological 030304 developmental biology 0303 health sciences Lung medicine.diagnostic_test business.industry lcsh:R fibrosis Public Health Environmental and Occupational Health Dust Middle Aged medicine.disease 3. Good health respiratory tract diseases medicine.anatomical_structure 030228 respiratory system inflammation Female WTC Lymph September 11 Terrorist Attacks business |
Zdroj: | International Journal of Environmental Research and Public Health Volume 16 Issue 5 International Journal of Environmental Research and Public Health, Vol 16, Iss 5, p 815 (2019) |
ISSN: | 1660-4601 |
DOI: | 10.3390/ijerph16050815 |
Popis: | Sarcoid-like granulomatous diseases (SGD) have been previously identified in cohorts of World Trade Center (WTC) dust-exposed individuals. In the present studies, we analyzed lung and/or lymph node biopsies from patients referred to our clinic with suspected WTC dust-induced lung disease to evaluate potential pathophysiologic mechanisms. Histologic sections of lung and/or lymph node samples were analyzed for markers of injury, oxidative stress, inflammation, fibrosis, and epigenetic modifications. Out of seven patients examined, we diagnosed four with SGD and two with pulmonary fibrosis one was diagnosed later with SGD at another medical facility. Patients with SGD were predominantly white, obese men, who were less than 50 years old and never smoked. Cytochrome b5, cytokeratin 17, heme oxygenase-1, lipocalin-2, inducible nitric oxide synthase, cyclooxygenase 2, tumor necrosis factor &alpha ADP-ribosylation factor-like GTPase 11, mannose receptor-1, galectin-3, transforming growth factor &beta histone-3 and methylated histone-3 were identified in lung and lymph nodes at varying levels in all samples examined. Three of the biopsy samples with granulomas displayed peri-granulomatous fibrosis. These findings are important and suggest the potential of WTC dust-induced fibrotic sarcoid. It is likely that patient demographics and/or genetic factors influence the response to WTC dust injury and that these contribute to different pathological outcomes. |
Databáze: | OpenAIRE |
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