Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers

Autor: Iris Udasin, Jessica A. Cervelli, Jared Radbel, Sabiha Hussain, Jag Sunderram, Vasanthi R. Sunil, Jeffrey D. Laskin, Debra L. Laskin, Malik Deen, Howard M. Kipen, Robert Laumbach, Kinal N. Vayas
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Environmental Research and Public Health
Volume 16
Issue 5
International Journal of Environmental Research and Public Health, Vol 16, Iss 5, p 815 (2019)
ISSN: 1660-4601
DOI: 10.3390/ijerph16050815
Popis: Sarcoid-like granulomatous diseases (SGD) have been previously identified in cohorts of World Trade Center (WTC) dust-exposed individuals. In the present studies, we analyzed lung and/or lymph node biopsies from patients referred to our clinic with suspected WTC dust-induced lung disease to evaluate potential pathophysiologic mechanisms. Histologic sections of lung and/or lymph node samples were analyzed for markers of injury, oxidative stress, inflammation, fibrosis, and epigenetic modifications. Out of seven patients examined, we diagnosed four with SGD and two with pulmonary fibrosis
one was diagnosed later with SGD at another medical facility. Patients with SGD were predominantly white, obese men, who were less than 50 years old and never smoked. Cytochrome b5, cytokeratin 17, heme oxygenase-1, lipocalin-2, inducible nitric oxide synthase, cyclooxygenase 2, tumor necrosis factor &alpha
ADP-ribosylation factor-like GTPase 11, mannose receptor-1, galectin-3, transforming growth factor &beta
histone-3 and methylated histone-3 were identified in lung and lymph nodes at varying levels in all samples examined. Three of the biopsy samples with granulomas displayed peri-granulomatous fibrosis. These findings are important and suggest the potential of WTC dust-induced fibrotic sarcoid. It is likely that patient demographics and/or genetic factors influence the response to WTC dust injury and that these contribute to different pathological outcomes.
Databáze: OpenAIRE