Effect of selenium (Se) on plasma ACTH, β-endorphin, corticosterone and glucose in rat: influence of adrenal enucleation and metyrapone pretreatment
| Autor: | Hamid R. Rasekh, Vani K. Nonavinakere, Ronaldo A. Potmis, Johnnie L. Early |
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| Rok vydání: | 1993 |
| Předmět: |
Blood Glucose
Male endocrine system medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Adrenocorticotropic hormone Toxicology Rats Sprague-Dawley Selenium chemistry.chemical_compound Adrenocorticotropic Hormone Corticosterone Internal medicine medicine Animals Saline Metyrapone beta-Endorphin Rats Endocrinology Mechanism of action chemistry Adrenal Medulla Toxicity medicine.symptom hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | Toxicology. 79:1-9 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(93)90201-3 |
| Popis: | The effects of acute treatment (i.p.) with selenium (Se) on glucoregulation, by measuring plasma levels of adrenocorticotropic hormone (ACTH), beta-endorphin (beta-EN), corticosterone (CORT) and glucose over time, were investigated. The hormones of the hypothalamic-pituitary adrenal (HPA) axis, were measured after treating rats with saline, Se: 1.6 mg/kg, or 3.8 mg/kg. Blood samples were collected before, 30, 60 and 90 min following injection. The results show that i.p. administration of Se (both doses) induce a rise in plasma ACTH, and beta-EN (P < 0.01). Plasma CORT and glucose levels also rose sharply by 30 min (P < 0.05). Corticosterone levels were increased in a dose-dependent fashion over the ensuing hour. Bilateral adrenal demedullation resulted in the abolishment of the Se-induced rise in plasma glucose. Pretreatment with metyrapone (300 mg/kg) was found to delay the Se-induced rise in plasma glucose. The results indicate that after a Se challenge the HPA axis is activated. In addition, CORT was found to be essential in the Se-induced rise in plasma glucose. |
| Databáze: | OpenAIRE |
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