Oral exposure to low-dose bisphenol A aggravates testosterone-induced benign hyperplasia prostate in rats
| Autor: | Gui-Ming Liu, Xiang-Yun Liu, Zu-Yue Sun, Gui-Lin He, Jianhui Wu, Xiu-Rong Jiang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Bisphenol A medicine.drug_class Health Toxicology and Mutagenesis Prostatic Hyperplasia Administration Oral Endocrine Disruptors Toxicology Severity of Illness Index Rats Sprague-Dawley chemistry.chemical_compound Phenols In vivo Prostate Internal medicine medicine Animals Testosterone Estrogens Non-Steroidal Benzhydryl Compounds Dose-Response Relationship Drug Estradiol urogenital system business.industry Public Health Environmental and Occupational Health Dihydrotestosterone Epithelial Cells Organ Size Hyperplasia Prostate-Specific Antigen medicine.disease Androgen Prolactin Rats Disease Models Animal Xenoestrogen medicine.anatomical_structure Endocrinology chemistry Estrogen business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Toxicology and industrial health. 27(9) |
| ISSN: | 1477-0393 |
| Popis: | The declining level of androgen during aging, associated with an inclining level of estrogen, has been hypothesized to be important in the development of benign prostatic hyperplasia (BPH). Within physiologic range, increasing estrogen levels can stimulate prostate to develop and permanently increase prostate size. As an estrogenic endocrine disruptor, bisphenol A (BPA) might be stimulatory to prostate development. We further hypothesized that low dose BPA could induce hyperplasia prostate to proliferate and aggravate the symptom of BPH in male SD rats. BPH was induced by testosterone and then treated with BPA (10, 30, or 90 μg/kg, i.g., daily), 17β-estradiol (E2; 50.0 μg/kg, s.c., daily), or vehicle for 4 weeks. We found that weight and volume in rats treated with low dose BPA (10 μg/kg) was higher than that of model control, and BPA significantly increased the relative weight of prostate (p < 0.01). For prostate lobes, BPA 10 μg/kg/day significantly increased relative weight of ventral prostate (VP), weight and relative weight of dorsolateral prostate (DLP) (p < 0.05). And histopathology results showed that height of epithelial cell (HEC) of VP and DLP in BPA group were significantly higher than that of model control (p < 0.01). BPA could also decrease testostertone level and increase prostate-specific antigen level. E2 treatment also showed an obvious effect on relative weight of VP and DLP, HEC, and hormone levels. We concluded that environment exposure to low dose of BPA may induce prostate to proliferate and aggravate testosterone-induced benign hyperplasia prostate in rats. |
| Databáze: | OpenAIRE |
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