Encapsulation Preserves Antioxidant and Antidiabetic Activities of Cactus Acid Fruit Bioactive Compounds under Simulated Digestion Conditions

Autor: Laura N. Afanador-Barajas, Rafael G. Campos-Montiel, Andrea Paloma Zepeda-Velásquez, Fabián Fernández-Luqueño, Armando Peláez-Acero, Gabriela Medina-Pérez, Melitón Jesús Franco-Fernández, José Antonio Estefes-Duarte
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Cactaceae
Antioxidant
xoconostle
030309 nutrition & dietetics
medicine.drug_class
medicine.medical_treatment
Phytochemicals
Anti-Inflammatory Agents
Betalains
Pharmaceutical Science
Immunostimulant
Article
Antioxidants
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
lcsh:Organic chemistry
Phenols
Drug Discovery
medicine
Hypoglycemic Agents
Glycoside Hydrolase Inhibitors
Food science
Physical and Theoretical Chemistry
chemistry.chemical_classification
Flavonoids
0303 health sciences
Gastrointestinal tract
Plant Extracts
Organic Chemistry
micro emulsions
Polyphenols
alpha-Glucosidases
04 agricultural and veterinary sciences
040401 food science
enzymatic inhibition
Enzyme
chemistry
Chemistry (miscellaneous)
Polyphenol
Fruit
Cactus
diabetes mellitus
Molecular Medicine
Digestion
alpha-Amylases
Zdroj: Molecules
Molecules, Vol 25, Iss 5736, p 5736 (2020)
Volume 25
Issue 23
ISSN: 1420-3049
Popis: Cactus acid fruit (Xoconostle) has been studied due its content of bioactive compounds. Traditional Mexican medicine attributes hypoglycemic, hypocholesterolemic, anti-inflammatory, antiulcerogenic and immunostimulant properties among others. The bioactive compounds contained in xoconostle have shown their ability to inhibit digestive enzymes such as &alpha
amylase and &alpha
glucosidase. Unfortunately, polyphenols and antioxidants in general are molecules susceptible to degradation due to storage conditions, (temperature, oxygen and light) or the gastrointestinal tract, which limits its activity and compromises its potential beneficial effect on health. The objectives of this work were to evaluate the stability, antioxidant and antidiabetic activity of encapsulated extract of xoconostle within double emulsions (water-in-oil-in-water) during storage conditions and simulated digestion. Total phenols, flavonoids, betalains, antioxidant activity, &alpha
glucosidase inhibition were measured before and after the preparation of double emulsions and during the simulation of digestion. The ED40% (treatment with 40% of xoconostle extract) treatment showed the highest percentage of inhibition of &alpha
glucosidase in all phases of digestion. The inhibitory activity of &alpha
glucosidase related to antidiabetic activity was higher in microencapsulated extracts than the non-encapsulated extracts. These results confirm the viability of encapsulation systems based on double emulsions to encapsulate and protect natural antidiabetic compounds.
Databáze: OpenAIRE
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