Expansion, Reexpansion, and Recall-Like Expansion of Vγ2Vδ2 T Cells in Smallpox Vaccination and Monkeypox Virus Infection
| Autor: | Zheng W. Chen, Richard Wang, Crystal Y. Chen, Huiyong Wei, Dan Huang, Lingyun Shao, Wenhong Zhang, Ling Shen, Jialin Jin |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
viruses
Immunology Organophosphonates Vaccinia virus Lymphocyte Activation Antiviral Agents Microbiology Virus Cytosine Interferon-gamma Monkeypox chemistry.chemical_compound T-Lymphocyte Subsets Virology Vaccines and Antiviral Agents medicine Animals Poxviridae Orthopoxvirus Monkeypox virus Smallpox vaccine Lung biology Receptors Antigen T-Cell gamma-delta T lymphocyte biology.organism_classification medicine.disease Macaca fascicularis chemistry Insect Science Female Vaccinia Cidofovir Smallpox Vaccine |
| Zdroj: | Journal of Virology. 83:11959-11965 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.00689-09 |
| Popis: | Little is known about the in vivo kinetics of T-cell responses in smallpox/monkeypox. We showed that macaque Vγ2Vδ2 T cells underwent 3-week-long expansion after smallpox vaccine immunization and displayed simple reexpansion in association with sterile anti-monkeypox virus (anti-MPV) immunity after MPV challenge. Virus-activated Vγ2Vδ2 T cells exhibited gamma interferon-producing effector function after phosphoantigen stimulation. Surprisingly, like αβ T cells, suboptimally primed Vγ2Vδ2 T cells in vaccinia virus/cidofovir-covaccinated macaques mounted major recall-like expansion after MPV challenge. Finally, Vγ2Vδ2 T cells localized in inflamed lung tissues for potential regulation. Our studies provide the first in vivo evidence that viruses, despite their inability to produce exogenous phosphoantigen, can induce expansion, reexpansion, and recall-like expansion of Vγ2Vδ2 T cells and stimulate their antimicrobial cytokine response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|