Bone Invasion by Walker 256 Carcinoma, Line A in Young and Adult Rats: Effects of Etidronate
| Autor: | Eugenio Scanziani, Laura De Francesco, Massimo Sabatini, Amalia Guaitani, Ivan Bartošek, Donatella Bassani, Giovanni Coccioli |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
musculoskeletal diseases Cancer Research Osteolysis business.industry Age Factors Etidronic Acid Rats Inbred Strains General Medicine Anatomy medicine.disease Bone and Bones Walker 256 carcinoma Rats Oncology Male rats Animals Medicine Calcium Neoplasm Invasiveness Tibia Carcinoma 256 Walker Line (text file) business |
| Zdroj: | Oncology. 47:160-165 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000226810 |
| Popis: | Line A of Walker 256 carcinoma implanted in the muscle adjacent to the tibia of young (6 weeks) and adult (9 months) male rats invaded the bone. Osteolysis and reactive growth were greater in the bone of young animals than in adults. Ethane-1-hydroxy-1, 1-bisphosphonate prevented bone lysis and tumor invasion of the cortex both in young and adult animals. This model may be useful for studies of age-related differences in tumor infiltration into the bone and for investigating drug effects on this process. |
| Databáze: | OpenAIRE |
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