A genetic approach to examine the relationship between vitamin B12 status and metabolic traits in a South Asian population
| Autor: | S. Sarkar, Karani Santhanakrishnan Vimaleswaran, Julie A. Lovegrove, Shelini Surendran, Basma Ellahi, R. Lankeshwara, Ranil Jayawardena, D. J. Anthony, K. Wetthasinghe, Sooad Alsulami |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
education.field_of_study
Waist business.industry Endocrinology Diabetes and Metabolism Population fungi Physiology nutritional and metabolic diseases 030209 endocrinology & metabolism Single-nucleotide polymorphism Anthropometry Q1 medicine.disease Obesity 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal Medicine medicine Observational study 030212 general & internal medicine Vitamin B12 education business RA |
| ISSN: | 1998-3832 0973-3930 |
| Popis: | Background\ud Observational studies in South Asian populations have suggested an association between vitamin B12 status and metabolic traits; however, the findings have been inconclusive. Hence, the aim of the present study was to use a genetic approach to explore the relationship between metabolic traits and vitamin B12 status in a Sri Lankan population and to investigate whether these relationships were modified by dietary intake.\ud \ud Methods\ud A total of 109 Sinhalese adults (61 men and 48 women aged 25–50 years) from Colombo City underwent anthropometric and biochemical measurements, dietary intake analysis, and genetic tests. Genetic risk scores (GRS) based on 10 metabolic single nucleotide polymorphisms (SNPs) (metabolic-GRS) and 10 vitamin B12 SNPs (B12-GRS) were constructed.\ud \ud Results\ud The B12-GRS was significantly associated with serum vitamin B12 (p = 0.008) but not with metabolic traits (p > 0.05), whereas the metabolic-GRS had no effect on metabolic traits (p > 0.05) and vitamin B12 concentrations (p > 0.05). An interaction was observed between B12-GRS and protein energy intake (%) on waist circumference (p = 0.002). Interactions were also seen between the metabolic-GRS and carbohydrate energy intake (%) on waist-to-hip ratio (p = 0.015).\ud \ud Conclusion\ud Our findings suggest that a genetically lowered vitamin B12 concentration may have an impact on central obesity in the presence of a dietary influence; however, our study failed to provide evidence for an impact of metabolic-GRS on lowering B12 concentrations. Given that our study has a small sample size, further large studies are required to confirm our findings. |
| Databáze: | OpenAIRE |
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