Nutritional parameters affecting erythrocyte polyamine levels in cancer patients
| Autor: | V B Grossie, M Foulkes, David M. Ota, Kenji Nishioka |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Parenteral Nutrition Cancer Research medicine.medical_specialty Erythrocytes Spermine chemistry.chemical_compound Neoplasms Internal medicine Preoperative Care Polyamines medicine Humans Neoplasm Metastasis Aged Neoplasm Staging chemistry.chemical_classification biology business.industry Cancer Blood Proteins Middle Aged medicine.disease Spermidine Transthyretin Malnutrition Endocrinology Oncology chemistry Transferrin biology.protein Putrescine Female Parenteral Nutrition Total Polyamine business |
| Zdroj: | Journal of Clinical Oncology. 2:1157-1164 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.1984.2.10.1157 |
| Popis: | Changes in erythrocyte polyamine levels during intravenous hyperalimentation in cancer and noncancer patients were determined, and the influence of host nutritional status on polyamine metabolism was analyzed. RBC putrescine (P less than .001), spermidine (P less than .01), and spermine (P less than .005) levels, and the putrescine-spermidine ratio (P less than .001) increased in the cancer group while no significant increases were noted in the noncancer group. The degree of malnutrition, based on body weight loss and plasma albumin, transferrin, prealbumin, and retinol-binding protein levels, was significantly greater in the cancer group than in the noncancer group, giving rise to the possibility that repletion of nutritional deficits in host tissues could have contributed to the rise in RBC polyamines. When cancer patients of similar nutritional status were matched with the noncancer group, increases in RBC putrescine level and putrescine-spermidine ratio were noted in the selected cancer patients. These results suggest that correction of nutritional deficits did not contribute significantly to the RBC polyamine pool and that increases in RBC polyamines during intravenous hyperalimentation were related to the presence of tumor. |
| Databáze: | OpenAIRE |
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