Structurally related glucosylated liposomes: correlation of physicochemical and biological features
Autor: | Giovanna Mancini, Giuseppina Bozzuto, Maria Condello, Antonella Piozzi, Agnese Molinari, Alessandro Mauceri, Luciano Galantini, Luisa Giansanti |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
agglutination
Biocompatibility Surface Properties media_common.quotation_subject Biophysics Breast Neoplasms 02 engineering and technology 01 natural sciences Biochemistry Flow cytometry active drug delivery glucosylated liposomes human breast cancer cells lectins Surface-Active Agents In vivo Cell Line Tumor 0103 physical sciences Amphiphile medicine Humans Lipid bilayer Internalization media_common Liposome Microscopy Confocal 010304 chemical physics medicine.diagnostic_test Chemistry Cell Biology Flow Cytometry 021001 nanoscience & nanotechnology carbohydrates (lipids) Agglutination (biology) Glucose Liposomes Female lipids (amino acids peptides and proteins) Glycolipids 0210 nano-technology Hydrophobic and Hydrophilic Interactions |
Popis: | Liposomes functionalized on their surface with carbohydrates (glycoliposomes) represent an optimal approach for targeting of drugs to diseased tissues in vivo, thanks to biocompatibility, low toxicity and easy manufacturing of these lipid nanoparticles. Here we report on the study of liposomes including a novel glycosylated amphiphile and on the comparison of their features with those of glycosylated analogues described previously. Further, the capability of the different glucosylated formulations to interact with three breast cancer cell lines was investigated. Our results show that the hydrophobic portion of the lipid bilayer strongly influences both the properties and the internalization of glycosylated liposomes. |
Databáze: | OpenAIRE |
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