Hyponatraemia and cerebral oedema due to a modafinil overdose
| Autor: | Rohan Kandasamy, Felix May, Viktorija Kaminskaite |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_treatment Brain Edema Modafinil 030204 cardiovascular system & hematology Aspiration pneumonia law.invention 03 medical and health sciences 0302 clinical medicine law mental disorders medicine Humans 030212 general & internal medicine Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions business.industry Glasgow Coma Scale General Medicine Emergency department medicine.disease Intensive care unit Stimulant Anesthesia Etiology Vomiting Central Nervous System Stimulants Drug Overdose medicine.symptom business Hyponatremia medicine.drug |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2020-234530 |
| Popis: | Modafinil is a non-amphetamine stimulant that is prescribed for narcolepsy-associated sleepiness as well as reported off-licence uses among university students looking to improve wakefulness and focus. There is limited information in the medical literature about supratherapeutic modafinil dosage, symptomatology and management of overdose. We report a case of a healthy 32-year-old man who was found unconscious, having vomited, with an empty modafinil blister strip. At the emergency department, he presented with reduced Glasgow Coma Scale and prolonged episodes of vomiting. This acute presentation was conservatively managed in the intensive care unit. Antibiotics were also given for a suspected aspiration pneumonia. CT of the head showed cerebral oedema and biochemistry investigations revealed hyponatraemia. Result aetiology was unclear, however, it has been theorised to be secondary to a sizeable modafinil overdose. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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