Interaction of the Dopaminergic and Serotonergic Systems Significantly Influences the Risk for Multisomatoform Disorder: A Controlled Pilot Study
| Autor: | Ulrich Lehmann, Dennis Buers, Lisa Pahl, Jana Jakobi, Matthias Karst, Anh-Thu Tran, Manfred Stuhrmann, Lilly Volkmann, Michael Bernateck |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Serotonin Candidate gene Dopamine Pilot Projects Single-nucleotide polymorphism Biology Serotonergic Polymorphism Single Nucleotide Risk Factors Genotype Humans SNP Genetic Predisposition to Disease Allele Somatoform Disorders Genetics (clinical) Genetics Haplotype Dopaminergic General Medicine Middle Aged Haplotypes Case-Control Studies Female |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 16:892-896 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2011.0329 |
| Popis: | The etiology of multisomatoform disorder (MSD) is largely unknown, but an influence of genetic factors is likely. Since pain is a major component of MSD and dopamine as well as serotonin are involved in pain pathways, genes of the dopaminergic and serotonergic system are promising candidate genes and we assumed that polymorphisms could be associated with MSD. One hundred forty-nine patients with MSD and 149 age- and gender-matched healthy controls participated in this study. DNA from all participants was genotyped for 22 single nucleotide polymorphisms (SNPs) within genes of the dopaminergic and serotonergic system by polymerase chain reaction, a restriction enzyme analysis, and pyrosequencing. The distribution of SNP alleles, genotypes, and haplotypes was compared between patients and controls. Neither an allelic nor a genotypic association was found for any individual SNP, but testing for a haplotypic association revealed that a haplotype of the serotonergic genes HT(1B) and HT(1D) indicated a lower risk. However, this statistically insignificant protective effect became highly significant on the background of two DAT1 haplotypes. Interestingly, if these two DAT1 haplotypes are analyzed without considering the serotonergic genes as confounders, they are significantly associated with an enhanced risk. Taking into account observations from recent publications, this apparent contradiction might be explained with the complex interaction of the dopaminergic and serotonergic systems. To conclude, our results reveal an involvement of polymorphisms in dopaminergic and serotonergic genes in the etiology of MSD in patients of German descent, but their exact role in MSD requires further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|