Peripheral T-cell Lymphomas With Cytotoxic Phenotype in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
| Autor: | Nancy L. Harris, Daniel F. Boyer, Neal I. Lindeman, Judith A. Ferry |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Time Factors Chronic lymphocytic leukemia Granzymes Immunophenotyping Pathology and Forensic Medicine Fatal Outcome immune system diseases hemic and lymphatic diseases Biomarkers Tumor medicine Humans Anaplastic lymphoma kinase Anaplastic Lymphoma Kinase Anaplastic large-cell lymphoma Aged CD20 biology Perforin business.industry Large cell Lymphoma T-Cell Peripheral Receptor Protein-Tyrosine Kinases Middle Aged medicine.disease Immunohistochemistry Leukemia Lymphocytic Chronic B-Cell BCL10 Peripheral T-cell lymphoma Lymphoma Phenotype Treatment Outcome biology.protein Cancer research Lymphoma Large-Cell Anaplastic Female Surgery Anatomy business T-Lymphocytes Cytotoxic |
| Zdroj: | American Journal of Surgical Pathology. 38:279-288 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/pas.0000000000000140 |
| Popis: | Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is relatively common, and patients occasionally develop other neoplasms; however, patients who develop other types of lymphomas are rare. We encountered 3 patients with CLL/SLL (one 59-y-old man and 2 women aged 56 and 66 y) who developed T-cell lymphomas. Both women developed ALK anaplastic large cell lymphomas (ALCLs), whereas the man developed CD8 peripheral T-cell lymphoma, not otherwise specified. All 3 T-cell lymphomas expressed granzyme B and perforin, indicating a cytotoxic immunophenotype. In 1 case, the first presentation was a lymph nodal composite lymphoma. In the other 2 cases, the T-cell lymphomas arose |
| Databáze: | OpenAIRE |
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