Correlation between optic nerve head structural parameters and glaucomatous visual field indices
| Autor: | Masahiro Zako, Masahiko Gosho, Kyoichi Mizumoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
visual field
medicine.medical_specialty genetic structures retinal nerve fiber layer thickness Nerve fiber layer Glaucoma Correlation Optical coherence tomography Ophthalmology Bruch’s membrane opening-minimum rim width Medicine Rank correlation Original Research medicine.diagnostic_test business.industry Clinical Ophthalmology medicine.disease eye diseases Visual field medicine.anatomical_structure glaucoma spectral domain optical coherence tomography rim area Optic nerve sense organs Akaike information criterion business |
| Zdroj: | Clinical Ophthalmology (Auckland, N.Z.) |
| ISSN: | 1177-5483 1177-5467 |
| Popis: | Kyoichi Mizumoto,1 Masahiko Gosho,2 Masahiro Zako1 1Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan; 2Advanced Medical Research Center, Aichi Medical University, Nagakute, Aichi, Japan Abstract: We examined associations between optic nerve head structural parameters and glaucomatous visual field indices. The study population included patients with glaucomatous optic neuropathy who were evaluated at Aichi Medical University, Nagakute, Aichi, Japan, from October 2010to January 2011. A total of 57eyes from 33patients were assessed. We measured visual field using a Humphrey field analyzer, peripapillary retinal nerve fiber layer thickness (RNFL-T), and Bruch’s membrane opening-minimum rim width (BMO-MRW) using spectral domain optical coherence tomography, and rim area with referring three-dimensional photography. Spearman’s rank correlation coefficients were calculated between the threshold of visual sensitivity or total deviation of visual field and the following five optic nerve head structural parameters: RNFL-T length, BMO-MRW length, rim area, and calculated RNFL-T and BMO-MRW volumes (each length multiplied by rim area). The Akaike information criterion was calculated to determine which structural parameter was the best predictor of each visual field index. Threshold of visual sensitivity had correlation coefficients of 0.23with global sector of RNFL-T, 0.32with BMO-MRW, 0.14with rim area, 0.21with RNFL-T volume, and 0.26with BMO-MRW volume. The correlation coefficients for each parameter with total deviation of visual field were 0.22, 0.33, 0.28, 0.36, and 0.37, respectively. The Akaike information criterion of BMO-MRW showed the smallest values in analyses of both threshold of visual sensitivity and total deviation. The present results show that RNFL-T volume and BMO-MRW volume were more strongly correlated with total deviation than BMO-MRW, but BMO-MRW appeared to be the best predictor of the two glaucomatous visual field indices. Keywords: Bruch’s membrane opening-minimum rim width, glaucoma, retinal nerve fiber layer thickness, rim area, spectral domain optical coherence tomography, visual field |
| Databáze: | OpenAIRE |
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