| Autor: |
Fanya Woll, Leo Rubenstein, Harold Lepow, Harry Greisman |
| Rok vydání: |
1949 |
| Předmět: |
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| Zdroj: |
The American journal of medicine. 7(3) |
| ISSN: |
0002-9343 |
| Popis: |
Studies were made on the serum of a proved case of polyarteritis nodosa in which the appearance of a spontaneous precipitate at 4 °c. had been noted. The observed spontaneously precipitable protein differed from previously reported "cold fractions" or "cryoglobulins" in not redissolving at room temperature. Electrophoretic studies indicated that it is one component of the group of gamma globulins. The observed spontaneously precipitable protein also appeared in other cases—but not always—in which there was a reversal of the albumin/globulin ratio in the presence of a strongly positive cephalin floc-culation reaction and of azotemia. The total serum protein was not actually elevated but it was usually increased from a relatively low value to a normal or slightly high normal with progress of the disease. Since this same type of precipitate had been observed in two other proved cases of polyarteritis nodosa, the suggestion is offered that polyarteritis nodosa should be suspected when an irreversible spontaneous protein precipitate appears in the serum of a patient with a bizarre clinical picture. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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