Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey
| Autor: | Mehmet Simsek, Zafer Turkoglu, Burçe Can Kuru, Ilkin Zindanci, Mukaddes Kavala, Emin Ozlu |
|---|---|
| Přispěvatelé: | [Belirlenecek] |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Epidemiology Mucocutaneous zone Dermatology Associations Vulgaris Foliaceus 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Region Oral mucosa Internal medicine Pemphigus foliaceus Autoantibodies Original Paper treatment integumentary system business.industry Mortality rate Istanbul turkey Pemphigus vulgaris pemphigus 030206 dentistry medicine.disease RC31-1245 mortality Turkish Patients Pemphigus medicine.anatomical_structure RL1-803 030220 oncology & carcinogenesis Population study business |
| Zdroj: | Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii Advances in Dermatology and Allergology, Vol 37, Iss 1, Pp 23-28 (2020) |
| ISSN: | 1642-395X |
| DOI: | 10.5114/ada.2020.93380 |
| Popis: | Introduction: Pemphigus is an autoimmune intra-epidermal bullous disease of the skin and mucosae. Aim: To retrospectively evaluate the course, prognosis and clinical features of pemphigus. Material and methods: The files of 196 pemphigus patients admitted to our clinic between December 1995 and December 2014 were collected and analysed. Results: The male to female ratio among patients was 1 : 1.88. Pemphigus vulgaris (PV) was the most common clinical variant observed in 175 (89.3%) of the patients, followed by pemphigus foliaceus (PF) in 14 (7.1%) of the patients. The mean patient age at disease onset was 50 years. PV presented itself as skin lesions in 55 (31.4%) of the patients and as oral mucosa lesions in 120 (68.6%) of the patients. Complete remission and treatment withdrawal were obtained in 112 (57.1%) of the patients, for a mean period of 2.91 +/- 2.66 years (range: 4 months to 13 years). The mortality rate was 6%, and relapse occurred in 16 (14.3%) of the patients for a mean relapse period of 2.15 +/- 1.88 years (range: 6 months to 7 years). Mucocutaneous pemphigus (MCP) was the major clinical pattern observed in 96 (49%) of the patients. Conclusions: Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis. WOS:000519592400024 2-s2.0-85082099926 PubMed: 32467679 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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