Does sequential embryo transfer improve pregnancy rate in patients with repeated implantation failure? A randomized control study
| Autor: | Ashraf Moawad, Hena Zaheer, Awatif Al-Bahr, Wael A. Ismail Madkour, Mahmoud Shaeer, Bassel Noah, Amr M. Salaheldin Abdelhamid |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
lcsh:QH471-489 Early Pregnancy Loss medicine.medical_treatment law.invention Randomized controlled trial law Obstetrics and Gynaecology medicine lcsh:Reproduction Sequential embryo transfer In patient Gynecology lcsh:R5-920 Repeated implantation failures In vitro fertilisation business.industry Obstetrics and Gynecology Embryo Oocyte Embryo transfer Pregnancy rate medicine.anatomical_structure Reproductive Medicine Anesthesia lcsh:Medicine (General) business |
| Zdroj: | Middle East Fertility Society Journal, Vol 20, Iss 4, Pp 255-261 (2015) |
| ISSN: | 1110-5690 |
| DOI: | 10.1016/j.mefs.2015.04.002 |
| Popis: | Background: Repeated failure of in vitro fertilization treatment is frustrating to the patients and their clinicians. Various treatment plans and a change of protocol have been suggested for “low responders”; however, patients who fail treatment repeatedly inspite of good quality embryos pose a special therapeutic challenge. Additional challenge would be imposed on that particular group when the local IVF regulating low does not permit surplus embryo freezing. Objective: To examine whether sequential transfer of embryos on day 3 and on day 5 after ovum pick-up improves IVF/ET success rates in patients with repeated consecutive IVF failures (⩾ 3 trials) compared to day 3 alone, with the background that local regulation prohibits embryo freezing. Study design: Randomized controlled study. Women scheduled for IVF/ET with repeated consecutive IVF failures (⩾ 3 trials) were randomized to either sequential transfer of embryos on day 3 and on day 5 after ovum pick-up (Group I = 74) or conventional day 3 transfer (Group II = 73) as a control. The primary outcome measures were clinical pregnancy rate and implantation rate. The secondary outcome measures were ongoing pregnancy rate and early pregnancy loss. Results: Baseline and cycle characteristics were comparable in both groups. Clinical pregnancy rate (per embryo transfer) was significantly higher in sequential ET group (37. 8%) compared to that in day 3 group (21.9%) (P value |
| Databáze: | OpenAIRE |
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