Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent
| Autor: | Gray R.A., Stott C.G., Jones N.A., Di Marzo V., Whalley B.J. |
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| Rok vydání: | 2020 |
| Předmět: |
genetic structures
medicine.medical_treatment TRPV1 Pharmacology digestive system Transient receptor potential channel Epilepsy medicine Pharmacology (medical) In patient Original Research seizures business.industry Generalized seizure cannabinoid medicine.disease digestive system diseases surgical procedures operative Anticonvulsant nervous system Complementary and alternative medicine Mechanism of action epilepsy CBD lipids (amino acids peptides and proteins) medicine.symptom anticonvulsant business Cannabidiol mechanism of action medicine.drug |
| Zdroj: | Cannabis and Cannabinoid Research Journal of cannabis therapeutics 5 (2020): 145–149. doi:10.1089/can.2019.0028 info:cnr-pdr/source/autori:Gray R.A.; Stott C.G.; Jones N.A.; Di Marzo V.; Di Marzo V.; Whalley B.J.; Whalley B.J./titolo:Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent/doi:10.1089%2Fcan.2019.0028/rivista:Journal of cannabis therapeutics/anno:2020/pagina_da:145/pagina_a:149/intervallo_pagine:145–149/volume:5 |
| ISSN: | 2378-8763 2578-5125 |
| DOI: | 10.1089/can.2019.0028 |
| Popis: | Introduction: Highly purified cannabidiol (CBD) (approved as Epidiolex® in the United States) has demonstrated efficacy with an acceptable safety profile in patients with Lennox-Gastaut or Dravet syndrome in four randomized controlled trials. CBD possesses affinity for many target classes with functional effects relevant to the pathophysiology of many disease types, including epilepsy. Although the mechanism of action of CBD underlying the reduction of seizures in humans is unknown, transient receptor potential vanilloid 1 (TRPV1) represents a plausible target because (1) CBD activates and then desensitizes TRPV1, (2) TRPV1 is overexpressed in models of temporal lobe epilepsy and patients with epilepsy, (3) and TRPV1 modulates neuronal excitability. Methods: To investigate a potential role of TRPV1 in the anticonvulsive effects of CBD, the effect of CBD on seizure threshold was assessed using a mouse maximal electroshock threshold model of generalized seizure in TRPV1 knockout and wildtype mice. The dose dependence of the CBD effect was determined and compared with that of the positive comparator diazepam and vehicle. Results: At 50 and 100 mg/kg, CBD significantly (p |
| Databáze: | OpenAIRE |
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