Adverse Events Induced by Nivolumab Plus Ipilimumab vs. Nivolumab Monotherapy among Cancer Patients: A Systematic Review and Meta-Analysis

Autor:	Kamat, Shweta, Patel, Jay, Brown, Britny R., Vyas, Ami
Rok vydání:	2022
Předmět:	Cancer Research Oncology General Medicine
Zdroj:	Cancer Investigation. 40:777-788
ISSN:	1532-4192 0735-7907
DOI:	10.1080/07357907.2022.2108827
Popis:	A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to examine treatment-related adverse events (TRAEs) for combination of nivolumab (NIVO) and ipilimumab (IPI) compared to NIVO monotherapy among cancer patients. We searched several databases to identify relevant RCTs. Meta-analysis was performed using random-effects model. In fourteen RCTs included in the study, we found that compared to NIVO monotherapy, combination NIVO + IPI increased the risk of any grade (Risk Ratio (RR) = 1.11), and grade 3 or 4 (RR = 1.95) TRAEs. Compared to NIVO, NIVO + IPI had higher risk for any grade colitis (RR = 4.52), pneumonitis (RR = 3.06), and diarrhea (RR = 1.68).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9dd4c7b10e216b03f15eae4cd7ec200 https://doi.org/10.1080/07357907.2022.2108827 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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