Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases
| Autor: | Magali Lacroix-Triki, Nadjla Alsadoun, Michel Parent, Pascal Wuithier, Marie-Hélène Koeb, Laurent Arnould, Romain Boidot, Isabelle Bedgedjian, Elsy El Alam, Gaëtan MacGrogan, Caroline Truntzer, Dan Medioni, Isabelle Robert |
|---|---|
| Přispěvatelé: | Département de Biologie et pathologie des tumeurs [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Département de Biopathologie (Institut Bergonié - CRLCC Bordeaux), Institut Bergonié [Bordeaux], Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR), Service d'Anatomie pathologique [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Cypath (Lyon), Département de Biopathologie [Institut Curie, Paris], Institut Curie [Paris], Pathologie Nord Unilabs, Centre de Pathologie (Tarbes), Atalante Pathologie (Rennes), Laboratoire d'anatomie pathologique [Besancon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Hôpital Jean Minjoz-Université de Franche-Comté (UFC), Medipath Cannes-Antibes-Grasse |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Proliferative index [SDV.CAN]Life Sciences [q-bio]/Cancer Breast Neoplasms Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Breast cancer Intraductal papilloma medicine Carcinoma Biomarkers Tumor Humans Breast Solid papillary carcinoma Aged Cell Proliferation business.industry Gene Expression Profiling Myoepithelial cell Papillary tumor Hyperplasia Middle Aged medicine.disease Immunohistochemistry Carcinoma Papillary Isocitrate Dehydrogenase 3. Good health 030104 developmental biology 030220 oncology & carcinogenesis Mutation Breast cancer Solid papillary carcinoma Female business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Modern Pathology Modern Pathology, Nature Publishing Group: Open Access Hybrid Model Option B, 2018, 31 (9), pp.1367-1380. ⟨10.1038/s41379-018-0047-1⟩ |
| ISSN: | 1530-0285 0893-3952 |
| DOI: | 10.1038/s41379-018-0047-1⟩ |
| Popis: | International audience; Solid papillary carcinoma with reverse polarity is a rare breast cancer of favorable prognosis that can be difficult to diagnose. We report here nine additional cases of this tumor, and we describe its morphologic, immunohistochemical and molecular profile in comparison to other types of papillary and micropapillary lesions of the breast that are intraductal papilloma with usual ductal hyperplasia, encapsulated papillary carcinoma, solid papillary carcinoma and invasive micropapillary carcinoma. We studied nine cases of this special papillary tumor and six of each other types mentioned above. We found that solid papillary carcinoma with reverse polarity harbor specific morphologic features as cuboid or tall cells with abundant eosinophilic cytoplasms located at the basal pole giving the impression of reverse nuclear polarity. Nuclei were sometimes grooved. Immunohistochemistry demonstrated the lack of myoepithelial cells, as in encapsulated papillary carcinoma and solid papillary carcinoma, questioning their invasive nature. Seven of nine solid papillary carcinoma with reverse polarity showed a low Ki67 proliferative index (Ki67 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink