Resting-state fMRI study of acute migraine treatment with kinetic oscillation stimulation in nasal cavity
| Autor: | Tie-Qiang Li, Rolf G Hallin, J. E. Juto, Yanlu Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Visual Analog Scale Cognitive Neuroscience Independent component analysis (ICA) Migraine Disorders Rest Inferior frontal gyrus Sensory system lcsh:Computer applications to medicine. Medical informatics Vibration lcsh:RC346-429 Kinetic oscillatory stimulation (KOS) Superior temporal gyrus Intrinsic functional activity medicine Image Processing Computer-Assisted Humans Radiology Nuclear Medicine and imaging Resting-state fMRI Autonomic nervous system (ANS) lcsh:Neurology. Diseases of the nervous system Migraine Brain Mapping Principal Component Analysis medicine.diagnostic_test Resting state fMRI Regular Article Middle Aged medicine.disease Magnetic Resonance Imaging Oxygen Autonomic nervous system 3-Way ANOVA Kinetics Treatment Outcome Neurology nervous system lcsh:R858-859.7 Female Neurology (clinical) Nasal Cavity Functional magnetic resonance imaging Psychology Insula Neuroscience |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 12, Iss C, Pp 451-459 (2016) |
| ISSN: | 2213-1582 |
| Popis: | Kinetic oscillatory stimulation (KOS) in the nasal cavity is a non-invasive cranial nerve stimulation method with promising efficacy for acute migraine and other inflammatory disorders. For a better understanding of the underlying neurophysiological mechanisms of KOS treatment, we conducted a resting-state functional magnetic resonance imaging (fMRI) study of 10 acute migraine patients and 10 normal control subjects during KOS treatment in a 3 T clinical MRI scanner. The fMRI data were first processed using a group independent component analysis (ICA) method and then further analyzed with a voxel-wise 3-way ANOVA modeling and region of interest (ROI) of functional connectivity metrics. All migraine participants were relieved from their acute migraine symptoms after 10–20 min KOS treatment and remained migraine free for 3–6 months. The resting-state fMRI result indicates that migraine patients have altered intrinsic functional activity in the anterior cingulate, inferior frontal gyrus and middle/superior temporal gyrus. KOS treatment gave rise to up-regulated intrinsic functional activity for migraine patients in a number of brain regions involving the limbic and primary sensory systems, while down regulating temporally the activity for normal controls in a few brain areas, such as the right dorsal posterior insula and inferior frontal gyrus. The result of this study confirms the efficacy of KOS treatment for relieving acute migraine symptoms and reducing attack frequency. Resting-state fMRI measurements demonstrate that migraine is associated with aberrant intrinsic functional activity in the limbic and primary sensory systems. KOS in the nasal cavity gives rise to the adjustment of the intrinsic functional activity in the limbic and primary sensory networks and restores the physiological homeostasis in the autonomic nervous system. Highlights • Efficacy and neurological mechanisms underlying kinetic oscillatory stimulation treatment of migraine • Dependence of ICA (independent component analysis) results on the number of independent components. • Modulation of ANS (autonomic nervous system) function via the limbic network |
| Databáze: | OpenAIRE |
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