Yellow Fever Vaccine. V. Antibody Response in Monkeys Inoculated with Graded Doses of the 17D Vaccine
| Autor: | Thomas C. O'Brien, Robert K. Ginn, Richard A. Mason, Roy W. Trimmer, Nicola M. Tauraso |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Virus Cultivation
Yellow fever vaccine Kidney Injections Intramuscular Median lethal dose General Biochemistry Genetics and Molecular Biology Cell Line Lethal Dose 50 Mice Antigen Neutralization Tests medicine Animals General Pharmacology Toxicology and Pharmaceutics Antigens Viral General Immunology and Microbiology biology Complement Fixation Tests Vaccination Yellow fever Lethal dose Viral Vaccines Haplorhini General Medicine Hemagglutination Inhibition Tests Complement fixation test medicine.disease Virology Antibody Formation Immunology biology.protein Macaca Clinical Microbiology Virology and Immunology Yellow fever virus Antibody Arboviruses medicine.drug |
| Zdroj: | Applied Microbiology. 23:908-913 |
| ISSN: | 0003-6919 |
| DOI: | 10.1128/am.23.5.908-913.1972 |
| Popis: | A dosage equal to or greater than approximately 3.4 Dex (decimal exponent, log 10 ) weanling mouse intracerebral 50% lethal dose (LD 50 ) was sufficient to elicit a yellow fever antibody response, as determined by the plaque neutralization (PN) test, in better than 90% of vaccinated rhesus monkeys. Lower dosages were progressively less effective in terms of PN titers and the PN and hemagglutination-inhibition serological conversion rates observed. A dose of between 3.4 and 4.2 Dex weanling mouse intracerebral LD 50 , or one-tenth to one times the dosage recommended for man, provided an optimal antibody response in monkeys. In rhesus monkeys, in contrast to the findings for man, pre-existing yellow fever antibody did not interfere with the antibody response to yellow fever vaccine. The PN test was felt to be a more sensitive and specific indicator of yellow fever antibody in rhesus monkeys after vaccination than the hemagglutination inhibition or complement fixation tests. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|