Study of host-pathogen interactions to identify sustainable vaccine strategies to Marek's disease
Autor: | C. Butter, B. J. G. Baaten, T. F. Davison |
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Rok vydání: | 2004 |
Předmět: |
Marek Disease Vaccines
animal diseases viruses Immunology Biology Virus Immune system Immunity Marek Disease Animals Genetic Predisposition to Disease Pathogen Herpesvirus 2 Gallid Marek's disease Immunity Cellular General Veterinary Vaccination biology.organism_classification Acquired immune system Virology Antibody Formation Cytokines Chickens |
Zdroj: | Veterinary immunology and immunopathology. 100(3-4) |
ISSN: | 0165-2427 |
Popis: | Marek's disease virus is a highly cell-associated, lymphotropic alpha-herpesvirus that causes paralysis and neoplastic disease in chickens. The disease has been contained by vaccination with attenuated viruses and provides the first evidence for a malignant cancer being controlled by an antiviral vaccine. Marek's disease pathogenesis is complex, involving cytolytic and latent infection of lymphoid cells and oncogenic transformation of CD4+ T cells in susceptible chickens. Innate and adaptive immune responses develop in response to infection, but infection of lymphocytes results in immunosuppressive effects. The remarkable ability of MDV to escape immune responses by interacting with, and down-regulating, some key aspects of the immune system will be discussed in the context of genetic resistance. Resistance conferred by vaccination and the implications of targeting replicative stages of the virus will also be examined. |
Databáze: | OpenAIRE |
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