Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects
| Autor: | E. S. Zhavbert, V. I. Petrov, L. I. Bugaeva, O. I. Epshtein, S. A. Lebedeva, N. N. Yakovleva, Yu. L. Dugina, E. I. Surkova |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cannabinoid receptor Drug Evaluation Preclinical Motor Activity Pharmacology Antibodies General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Appetite Depressants Animals Receptor Chronic toxicity biology Chemistry Body Weight Biological activity General Medicine Angiotensin II Rats 030104 developmental biology biology.protein Female Antibody 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 161:252-256 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation containing a combination of affinity-purified antibodies to brain-specific S-100 protein and endothelial NO-synthase), Cardostin (release-active preparation containing a combination of affinity-purified antibodies to C-terminal fragment of angiotensin II type 1 receptor and endothelial NO-synthase), and Bation (release-active preparation containing a combination of affinity-purified antibodies to IFN-γ and CD4). We evaluated not only side and toxic effects, but also the relationships between these effects and pharmacological activities of the preparations. The data of preclinical toxicological studies of the release-active preparations can be used for prediction of their pharmacological activity. |
| Databáze: | OpenAIRE |
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