Selenoesters and Selenoanhydrides as Novel Agents Against Resistant Breast Cancer
| Autor: | Carmen Sanmartín, Annamária Kincses, Gabriella Spengler, Zsófia Vadas, Andrea Csonka, Enrique Domínguez-Álvarez, Márta Nové |
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| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
ABCB1 (P-glycoprotein) Cell Survival medicine.medical_treatment Apoptosis Antineoplastic Agents Breast Neoplasms Selenoesters Anhydrides 03 medical and health sciences 0302 clinical medicine Breast cancer Cell Line Tumor medicine Cytotoxic T cell Humans Doxorubicin MTT assay Selenium Compounds Chemotherapy business.industry Cancer Esters General Medicine medicine.disease Oncology Cell culture Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research Female business medicine.drug |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1791-7530 |
| Popis: | Background/Aim: Selenium-containing compounds are becoming new alternatives in experimental chemotherapy in order to overcome multidrug resistance in cancer. The main goal of this study was to determine whether combined treatment with new Se-compounds would increase the effect of conventional doxorubicin chemotherapy in breast cancer cell lines. Materials and Methods: Se-compounds were evaluated regarding their cytotoxic and apoptosis-inducing effect on MCF-7 and ATP-binding cassette subfamily B member 1 (ABCB1)-overexpressing KCR breast cancer cell lines. Moreover, the interaction of Se-compounds with doxorubicin was assessed using the MTT assay. Results: Selenoanhydride exerted a selective activity towards the doxorubicin-resistant KCR cell line overexpressing ABCB1. Among the selenoesters, only ketone-containing selenoesters exerted significant cytotoxic activity against MCF-7 and KCR cell lines and the Se-compounds acted synergistically with doxorubicin on the KCR cell line. Conclusion: The importance of the COSeCHCOCH and COSeCHCO(CH) moieties for the cytotoxic and adjuvant role of Se-compounds was highlighted. |
| Databáze: | OpenAIRE |
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