Nanočastice oxidu titaničitého modulujú lipidy u mladých potkanov
| Autor: | Dvořáková, Monika, Scsuková, Soňa, Rollerová, Eva, Žitňanová, Ingrid, Laubertová, Lucia |
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| Jazyk: | slovenština |
| Rok vydání: | 2021 |
| Předmět: | |
| DOI: | 10.5281/zenodo.4880865 |
| Popis: | SÚHRN Vývoj nanočastíc a nanomateriálov v biomedicíne zažíva v súčasnej dobe obrovskú expanziu. Tie isté vlastnosti, ktoré robia nové nanomateriály nenahraditeľné pre ich využitie, dokážu ovplyvniť ich interakciu s biologickými systémami a spôsobovať nežiaduce účinky. Cieľom našej štúdie bolo zistiť možný vzťah medzi koncentráciou lipoperoxidov ako predstaviteľov oxidačného poškodenia lipidov a expozíciou 1 % alebo 10 % LD50 TiO2 v dvoch rôznych životných fázach samíc potkanov. Pri porovnaní infantilných a dospelých potkanov sa u dospelých potkanov zistil významný pokles hladín lipoperoxidov. Podanie 1 % LD50 TiO2 infantilným potkanom v porovnaní s kontrolami vyvolalo pokles koncentrácie lipoperoxidov. Výsledky našich meraní dokazujú, že neonatálne podávanie TiO2 nanočastíc potkanom môže modulovať hladinu lipoperoxidov u samíc potkanov v závislosti od veku. ABSTRACT The development of nanoparticles and nanomaterials in biomedicine is currently experiencing a huge expansion. The same properties that make new nanomaterials irreplaceable for their use can affect their interaction with biological systems and cause side effects. The aim of our study was to determine the possible relationship between the concentration of lipoperoxides as representatives of oxidative damage to lipids and exposure to 1 % or 10 % LD50 TiO2 in two different life stages of female rats. When comparing infantile and adult rats, a significant decrease in lipoperoxide levels was found in adult rats. Administration of 1 % LD50 TiO2 to infant rats resulted in a decrease in lipoperoxide levels compared to controls. The results of our measurements demonstrate that neonatal administration of TiO2 nanoparticles to rats can modulate lipoperoxide levels in female rats with age. Práca bola finančne podporená z grantov Slovenskej agentúry pre výskum a vývoj No. APVV-15-0296 a APVV‒0404–11 (akronym NANOREPRO) a VEGA grant 2/0162/20. {"references":["Biola-Clier, M. et al. (2020): Titanium dioxide nanoparticles alter the cellular phosphoproteome in A549 cells. Nanomaterials. doi: 10.3390/nano10020185","El-Saadani, M. et al. (1989): A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. Journal of Lipid Research. doi: 10.1016/s0022- 2275(20)38354-1.","Hassanein, K. M. A. and El-Amir, Y. O. (2018): Ameliorative effects of thymoquinone on titanium dioxide nanoparticles induced acute toxicity in rats. International Journal of Veterinary Science and Medicine. doi: 10.1016/j.ijvsm.2018.02.002.","Hou, J. et al. (2019): Toxicity and mechanisms of action of titanium dioxide nanoparticles in living organisms. Journal of Environmental Sciences (China). doi: 10.1016/j.jes.2018.06.010","Gutiérrez Iglesias, E. et al. (2014): Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells. Free Radical Biology and Medicine. Elsevier Inc., 73, pp. 84–94. doi: 10.1016/j.freeradbiomed. 2014.04.026.","Huggins, C. B., Froehlich, J. P. (1966): High concentration of injected titanium dioxide in abdominal lymph nodes. The Journal of experimental medicine. doi: 10.1084/jem. 124.6.1099.","IARC (2010): Working Group on the Evaluation of Carcinogenic Risks to Humans. Carbon black, titanium dioxide, and talc. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.","Kermanizadeh, A. et al. (2015): The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review. Environmental and Molecular Mutagenesis. doi: 10.1002/em.21926.","Mostafavi, E., Soltantabar, P. and Webster, T. J. (2018): Nanotechnology and picotechnology: A new arena for translational medicine. Biomaterials in Translational Medicine: A Biomaterials Approach. doi: 10.1016/B978-0-12-813477- 1.00009-8.","Rollerova, E. et al. (2015): Titanium dioxide nanoparticles: Some aspects of toxicity/focus on the development. Endocrine Regulations. doi: 10.4149/endo_2015_02_97.","Shrivastava, R. et al. (2014): Effects of sub-acute exposure to TiO2 , ZnO and Al2 O3 nanoparticles on oxidative stress and histological changes in mouse liver and brain. Drug and Chemical Toxicology. doi: 10.3109/01480545.2013.866134","Tada-Oikawa, S. et al. (2016): Titanium dioxide particle type and concentration influence the inflammatory response in Caco-2 cells. International Journal of Molecular Sciences. doi: 10.3390/ijms17040576"]} |
| Databáze: | OpenAIRE |
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