Partial donor-specific tolerance to delayed skin grafts after rejection of hematopoietic cell graft
| Autor: | Murad Y. Yunusov, Christian S. Kuhr, Barry E. Storer, Billanna Hwang, Anna G. Taranova, William J. Hogan, Richard A. Nash, Yang Soo Kim, Rainer Storb, George E. Georges, George E. Sale, Marina Lesnikova, Kraig Abrams |
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| Rok vydání: | 2006 |
| Předmět: |
Graft Rejection
medicine.medical_specialty medicine.medical_treatment Urology Immune tolerance Dogs Intestine Small Immune Tolerance Medicine Animals Transplantation Homologous Skin graft loss Transplantation Hematopoietic cell Graft rejection biology business.industry Dog leukocyte antigen Graft Survival Hematopoietic Stem Cell Transplantation Skin Transplantation Tissue Donors Haematopoiesis surgical procedures operative Immunology Models Animal biology.protein Skin grafting business |
| Zdroj: | Transplantation. 82(5) |
| ISSN: | 0041-1337 |
| Popis: | Background. Donor-specific tolerance (DST) is induced after allogeneic hematopoietic cell transplantation (HCT) and is a potential strategy for prolonging survival of solid organ grafts. DST may persist in recipients with transient mixed hematopoietic chimerism (MC) when solid organ transplantation and HCT are done concomitantly. Methods. In a canine model of allogeneic HCT after nonmyeloablative conditioning, DST to skin grafts was evaluated in dog leukocyte antigen (DLA)-identical recipients with stable MC (n=11), or after rejection of the hematopoietic cell (HC) graft (n=19). Results. There was significant improvement in the survival of DLA-identical HC donor-derived skin grafts in recipients with MC compared to normal recipients (n=7; P |
| Databáze: | OpenAIRE |
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