Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer
| Autor: | Lukas Bubendorf, Spasenija Savic, Ralph A. Schmid, Nikola Cihoric, Inti Zlobec, Matthias Gugger, Didier Lardinois, Coya Tapia, Sandra Schneider, M Bichsel-Naef, I Ackermann |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
squamous cell carcinoma Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms 610 Medicine & health Biology amplification NSCLC Disease-Free Survival Internal medicine Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans Receptor Fibroblast Growth Factor Type 1 Stage (cooking) Lung cancer Molecular Diagnostics In Situ Hybridization Fluorescence Aged Aged 80 and over Lung Predictive marker Tissue microarray fluorescence in situ hybridisation Large cell Gene Amplification Middle Aged medicine.disease stomatognathic diseases medicine.anatomical_structure FGFR1 Tissue Array Analysis Carcinoma Squamous Cell 570 Life sciences biology Adenocarcinoma Female prognosis Neoplasm Recurrence Local |
| Zdroj: | British Journal of Cancer Cihoric, Nikola; Savic, Mirjana; Schneider, Sabine; Ackermann, I; Bichsel-Naef, Mirjam; Schmid, Ralph; Lardinois, D; Gugger, M; Bubendorf, Lukas; Zlobec, Inti; Tapia, Coya (2014). Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer. British journal of cancer, 110(12), pp. 2914-2922. Nature Publishing Group 10.1038/bjc.2014.229 |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2014.229 |
| Popis: | Background: Recently, fibroblast growth factor receptor 1 (FGFR1) was discovered in squamous cell carcinomas (SCC) of the lung with FGFR1 amplification described as a promising predictive marker for anti-FGFR inhibitor treatment. Only few data are available regarding prevalence, prognostic significance and clinico-pathological characteristics of FGFR1-amplified and early-stage non-small cell lung carcinomas (NSCLC). We therefore investigated the FGFR1 gene status in a large number of well-characterised early-stage NSCLC. Methods: FGFR1 gene status was evaluated using a commercially available fluorescent in situ hybridisation (FISH) probe on a tissue microarray (TMA). This TMA harbours 329 resected, formalin-fixed and paraffin-embedded, nodal-negative NSCLC with a UICC stage I–II. The FISH results were correlated with clinico-pathological features and overall survival (OS). Results: The prevalence of an FGFR1 amplification was 12.5% (41/329) and was significantly (P |
| Databáze: | OpenAIRE |
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