Discovery of CYT997: a structurally novel orally active microtubule targeting agent

Autor:	Max Joffe, Susan A. Charman, Michael Francis Harte, Harrison Sikanyika, David M. Shackleford, Andrew F. Wilks, Stephen Su, C. Elisabet Tranberg, Emmanuelle Fantino, Xianyong Bu, Neil Wilson, Christopher J. Burns
Rok vydání:	2009
Předmět:	Pyridines Clinical Biochemistry Pharmaceutical Science Administration Oral macromolecular substances Biochemistry Microtubules Structure-Activity Relationship Microtubule Cell Line Tumor Drug Discovery Structure–activity relationship Cytotoxic T cell Animals Humans Molecular Biology biology Tubulin Modulators Chemistry Drug discovery Organic Chemistry Small molecule Rats Tubulin Pyrimidines Cancer cell biology.protein Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 19(16)
ISSN:	1464-3405
Popis:	CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 are reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d0980f28c1e5ed7d17ed9812e165cb https://pubmed.ncbi.nlm.nih.gov/19616947 Zobrazit plný text záznamu Full Text from ScienceDirect