Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring
| Autor: | Brian Buckley, Min Liu, Roger Echelberger, Katherine A. McCaffrey, Heather B. Patisaul, Jinyan Cao, Emily Sluzas |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Offspring Nutritional Status Genistein Phytoestrogens Endocrine Disruptors Biology Weight Gain Toxicology Risk Assessment Article Eating chemistry.chemical_compound Phenols Pregnancy Internal medicine Lactation medicine Genistin Animals Weaning Obesity Sexual Maturation Benzhydryl Compounds Rats Wistar Age Factors Maternal Nutritional Physiological Phenomena medicine.anatomical_structure Endocrinology chemistry Prenatal Exposure Delayed Effects Soybean Proteins Animal Nutritional Physiological Phenomena Female Dietary Proteins medicine.symptom Weight gain Obesogen |
| Zdroj: | Reproductive Toxicology. 58:282-294 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2015.07.077 |
| Popis: | Endocrine disrupting compounds (EDCs) are hypothesized to promote obesity and early puberty but their interactive effects with hormonally active diets are poorly understood. Here we assessed individual and combinatorial effects of soy diet or the isoflavone genistein (GEN; administered as the aglycone genistin GIN) with bisphenol A (BPA) on body weight, ingestive behavior and female puberal onset in Wistar rats. Soy-fed dams gained less weight during pregnancy and, although they consumed more than dams on a soy-free diet during lactation, did not become heavier. Their offspring (both sexes), however, became significantly heavier (more pronounced in males) pre-weaning. Soy also enhanced food intake and accelerated female pubertal onset in the offspring. Notably, pubertal onset was also advanced in females placed on soy diet at weaning. Males exposed to BPA plus soy diet, but not BPA alone, had lighter testes. BPA had no independent effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect