Single-molecule trapping and measurement in solution
| Autor: | Maria I Bespalova, Sushanta Mahanta, Madhavi Krishnan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Optics and Photonics Materials science Nanotechnology Trapping 010402 general chemistry Key issues 01 natural sciences Biochemistry Solution phase 0104 chemical sciences Analytical Chemistry Kinetics 03 medical and health sciences Physical Entrapment Electrokinetic phenomena 030104 developmental biology Thermodynamics Molecule Fluid phase |
| Zdroj: | Current Opinion in Chemical Biology |
| ISSN: | 1367-5931 |
| DOI: | 10.1016/j.cbpa.2019.05.013 |
| Popis: | Trapping of a single molecule in the fluid phase was realized decades following developments in the gas-phase, because in some ways the solution phase posed a greater challenge. The key issues have since been addressed by several different means; techniques to confine nanometer scale entities in solution now abound and are gaining traction in a variety of single molecule studies. Available methods range from pure physical entrapment of a molecule on the one hand to electrokinetic and optical techniques, and approaches that exploit thermodynamic principles on the other. Some trapping techniques have also opened up new avenues to highly precise, accurate measurements of molecular physical properties in solution. |
| Databáze: | OpenAIRE |
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