National Trends in Hospitalization for Fever and Neutropenia in Children with Cancer, 2007-2014
| Autor: | Parth Bhatt, Smita Bhaskaran, Fredrick Dapaah-Siakwan, Vijay Gandhi Linga, Samir V. Patel, Mihir Dave, Neel S. Bhatt, Brian Zhu, Zeenia Billimoria, Anusha Lekshminarayanan, Samer Zaid-Kaylani, Riddhi Chaudhari, Sejal Savani, Keyur Donda |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Neutropenia Adolescent Databases Factual Fever Population Risk Assessment Cohort Studies 03 medical and health sciences 0302 clinical medicine Age Distribution 030225 pediatrics Neoplasms Risk of mortality Medicine Humans Hospital Costs Sex Distribution education Child Retrospective Studies education.field_of_study business.industry Mortality rate Incidence Length of Stay medicine.disease Pediatric cancer Survival Analysis United States Hospitalization Pneumonia 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health Female business Meningitis Febrile neutropenia |
| Zdroj: | The Journal of pediatrics. 202 |
| ISSN: | 1097-6833 |
| Popis: | To assess the trends of inpatient resource use and mortality in pediatric hospitalizations for fever with neutropenia in the US from 2007 to 2014.Using National (Nationwide) Inpatient Sample (NIS) and International Classification of Diseases, Ninth Revision, Clinical Modification codes, we studied pediatric cancer hospitalizations with fever with neutropenia between 2007 and 2014. Using appropriate weights for each NIS discharge, we created national estimates of median cost, length of stay, and in-hospital mortality rates.Between 2007 and 2014, there were 104 315 hospitalizations for pediatric fever with neutropenia. The number of weighted fever with neutropenia hospitalizations increased from 12.9 (2007) to 18.1 (2014) per 100 000 US population. A significant increase in fever with neutropenia hospitalizations trend was seen in the 5- to 14-year age group, male sex, all races, and in Midwest and Western US hospital regions. Overall mortality rate remained low at 0.75%, and the 15- to 19-year age group was at significantly greater risk of mortality (OR 2.23, 95% CI 1.36-3.68, P = .002). Sepsis, pneumonia, meningitis, and mycosis were the comorbidities with greater risk of mortality during fever with neutropenia hospitalizations. Median length of stay (2007: 4 days, 2014: 5 days, P .001) and cost of hospitalization (2007: $8771, 2014: $11 202, P .001) also significantly increased during the study period.Our study provides information regarding inpatient use associated with fever with neutropenia in pediatric hospitalizations. Continued research is needed to develop standardized risk stratification and cost-effective treatment strategies for fever with neutropenia hospitalizations considering increasing costs reported in our study. Future studies also are needed to address the greater observed mortality in adolescents with cancer. |
| Databáze: | OpenAIRE |
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