Haplotype‐based genome‐wide association studies reveal new loci for haematological and clinical–biochemical parameters in Large White pigs
| Autor: | Giuseppina Schiavo, Samuele Bovo, Stefania Dall'Olio, Mohamad Ballan, Luca Fontanesi, Maurizio Gallo |
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| Přispěvatelé: | Bovo, S., Ballan, M., Schiavo, G., Gallo, M., Dall'Olio, S., Fontanesi, L. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Population Sus scrofa Genome-wide association study Quantitative trait locus Biology 03 medical and health sciences Genetics medicine Animals education Mean corpuscular volume education.field_of_study medicine.diagnostic_test Haplotype 0402 animal and dairy science Large white 04 agricultural and veterinary sciences General Medicine 040201 dairy & animal science Genetic architecture 030104 developmental biology Haplotypes Italy Animal Science and Zoology Blood parameters Blood Chemical Analysis alkaline phosphatase blood parameter creatine kinase electrolyte enzyme erythrocyte leukocyte QTL Sus scrofa Genome-Wide Association Study |
| Popis: | We report haplotype-based GWASs for 33 blood parameters measured in 843 Italian Large White pigs. In the single-trait analysis, a total of 30 QTL for number of basophils, six erythrocyte traits (haemoglobin, haematocrit, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, mean corpuscular volume and red blood cell count) and two clinical-biochemical traits (alkaline phosphatase and Ca2+ contents) were identified. In the multiple-trait analysis, a total of five QTL affected three different clusters of traits. Only four of these QTL were already reported in the single-marker and multi-marker GWASs we previously carried out on the same pig population. QTL on SSC11 and SSC17 showed effects on multiple traits. These results further dissected the genetic architecture of parameters that could be used as proxies in breeding programmes for more complex traits. In addition, these results might help to better define the pig as an animal model for several blood-related biological functions. |
| Databáze: | OpenAIRE |
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