Erythema multiforme‐like lesions in children and COVID‐19

Autor: Silvia Escalada-Pellitero, Carlos Santonja, Jara Gaitero-Tristán, Isabel Colmenero, Antonio Torrelo, David Andina, Angela Hernández-Martín, Marta Bascuas-Arribas, José Antonio Alonso-Cadenas, Lucero Noguera-Morel, Mercedes de la Torre-Espi
Rok vydání: 2020
Předmět:
Male
skin
Pathology
medicine.medical_specialty
Necrosis
Adolescent
Coronavirus disease 2019 (COVID-19)
viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral
Case Report
Case Reports
Dermatology
SARS‐CoV‐2
Betacoronavirus
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
COVID‐19
Humans
Medicine
Pediatrics
Perinatology
and Child Health
pernio
Erythema multiforme
Child
skin and connective tissue diseases
Chilblains
Pandemics
Exanthem
Erythema Multiforme
SARS-CoV-2
business.industry
fungi
COVID-19
Spike Protein
medicine.disease
respiratory tract diseases
body regions
030220 oncology & carcinogenesis
Pediatrics
Perinatology and Child Health
Immunohistochemistry
Female
medicine.symptom
Coronavirus Infections
business
chilblain
Zdroj: Pediatric Dermatology
ISSN: 1525-1470
0736-8046
DOI: 10.1111/pde.14246
Popis: During examination of cases of chilblains in children and adolescents, we identified four patients who also showed skin lesions similar to erythema multiforme (EM). They had no other known triggers for EM. One of them had a positive PCR for SARS‐CoV‐2, while the other 3 were negative. Skin biopsies from two patients showed features not typical of EM, such as deep perivascular and perieccrine infiltrate and absence of necrosis of keratinocytes. Immunohistochemistry for SARS‐CoV/SARS‐CoV‐2 spike protein showed granular positivity in endothelial cells and epithelial cells of eccrine glands in both biopsies. All patients had an excellent outcome, and had minimal or no systemic symptoms. The coincidence of EM, a condition commonly related to viruses, and chilblains in the setting of COVID‐19, as well as the positivity for SARS‐CoV/SARS‐CoV‐2 spike protein by immunohistochemistry strongly suggest a link between EM‐like lesions and SARS‐CoV‐2.
Databáze: OpenAIRE
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