Modular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity
| Autor: | Shan Hazoor, Frank W. Foss, Su Yang, Yan Chang, Chad A. Brautigam, Zui Pan, He Dong |
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| Rok vydání: | 2021 |
| Předmět: |
Ions
Molecular Structure Chemistry Macromolecular Substances Organic Chemistry Cell Membrane Supramolecular chemistry Rational design Biochemistry Supramolecular assembly Membrane Drug delivery Membrane activity Biophysics Molecular Medicine Humans Self-assembly Molecular imaging Particle Size Peptides Molecular Biology HeLa Cells |
| Zdroj: | Chembiochem : a European journal of chemical biology. 22(22) |
| ISSN: | 1439-7633 |
| Popis: | The rational design of materials with cell-selective membrane activity is an effective strategy for the development of targeted molecular imaging and therapy. Here we report a new class of cationic multidomain peptides (MDPs) that can undergo enzyme-mediated molecular transformation followed by supramolecular assembly to form nanofibers in which cationic clusters are presented on a rigid β-sheet backbone. This structural transformation, which is induced by cells overexpressing the specific enzymes, led to a shift in the membrane perturbation potential of the MDPs, and consequently enhanced cell uptake and drug delivery efficacy. We envision the directed self-assembly based on modularly designed MDPs as a highly promising approach to generate dynamic supramolecular nanomaterials with emerging membrane activity for a range of disease targeted molecular imaging and therapy applications. |
| Databáze: | OpenAIRE |
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