COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)

Autor: John F. Crary, Kristine Yaffe, Kamar E. Ameen-Ali, Brian L. Edlow, Douglas H. Smith, Thomas J. Montine, Abigail C. Bretzin, Victoria E. Johnson, Daniel P. Perl, Thomas McCabe, Sidney R. Hinds, Lili-Naz Hazrati, Gabor G. Kovacs, Edward B. Lee, Julia Kofler, Rebecca D. Folkerth, Ramon Diaz-Arrastia, Kristen Dams-O'Connor, Geoffrey T. Manley, John Q. Trojanowski, Douglas J. Wiebe, David O. Okonkwo, William Stewart, C. Dirk Keene, Jean-Pierre Dollé, Etty Cortes, David F. Meaney, Diego Iacono
Rok vydání: 2021
Předmět:
Male
Gerontology
Neurology
Concussion
Disease
Neurodegenerative
Neurodegenerative disease
lcsh:RC346-429
Traumatic brain injury
Injury - Trauma - (Head and Spine)
Medicine
Stroke
Neuropathology
Chronic traumatic encephalopathy
Methodology Article
Brain
Neurodegenerative Diseases
Athletic Injuries
Neurological
Disease Progression
Autopsy
medicine.medical_specialty
Physical Injury - Accidents and Adverse Effects
Clinical Sciences
Tissue Banks
Traumatic Brain Injury (TBI)
Pathology and Forensic Medicine
Cellular and Molecular Neuroscience
Acquired Cognitive Impairment
Humans
Dementia
lcsh:Neurology. Diseases of the nervous system
Traumatic Head and Spine Injury
Aged
Information Services
business.industry
Neurosciences
medicine.disease
nervous system diseases
Brain Disorders
Good Health and Well Being
Athletes
Injury (total) Accidents/Adverse Effects
Biochemistry and Cell Biology
Neurology (clinical)
Injury - Traumatic brain injury
business
Zdroj: Acta neuropathologica communications, vol 9, iss 1
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-13 (2021)
Acta Neuropathologica Communications
ISSN: 2051-5960
Popis: Efforts to characterize the late effects of traumatic brain injury (TBI) have been in progress for some time. In recent years much of this activity has been directed towards reporting of chronic traumatic encephalopathy (CTE) in former contact sports athletes and others exposed to repetitive head impacts. However, the association between TBI and dementia risk has long been acknowledged outside of contact sports. Further, growing experience suggests a complex of neurodegenerative pathologies in those surviving TBI, which extends beyond CTE. Nevertheless, despite extensive research, we have scant knowledge of the mechanisms underlying TBI-related neurodegeneration (TReND) and its link to dementia. In part, this is due to the limited number of human brain samples linked to robust demographic and clinical information available for research. Here we detail a National Institutes for Neurological Disease and Stroke Center Without Walls project, the COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI), designed to address current limitations in tissue and research access and to advance understanding of the neuropathologies of TReND. As an international, multidisciplinary collaboration CONNECT-TBI brings together multiple experts across 13 institutions. In so doing, CONNECT-TBI unites the existing, comprehensive clinical and neuropathological datasets of multiple established research brain archives in TBI, with survivals ranging minutes to many decades and spanning diverse injury exposures. These existing tissue specimens will be supplemented by prospective brain banking and contribute to a centralized route of access to human tissue for research for investigators. Importantly, each new case will be subject to consensus neuropathology review by the CONNECT-TBI Expert Pathology Group. Herein we set out the CONNECT-TBI program structure and aims and, by way of an illustrative case, the approach to consensus evaluation of new case donations.
Databáze: OpenAIRE
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