A THEORY FOE A QUANTITATIVE INVESTIGATION OF THE TURNOVER OF IODINE IN THE THYROID GLAND

Autor:	N. J. Nadler
Rok vydání:	1958
Předmět:	chemistry.chemical_classification medicine.medical_specialty Chemistry Iodide Thyroid Thyroid Gland chemistry.chemical_element Metabolism Iodides Iodine Endocrinology medicine.anatomical_structure Internal medicine medicine Steady state (chemistry) Iodine metabolism
Zdroj:	Endocrinology. 62:758-767
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-62-6-758
Popis:	A theory was set up for the in vivo or in vitro investigation of the turnover of iodine in the thyroid gland using radioiodine. In this study, there was assumed to be a continuous passage into the gland of extracellular inorganic iodide and a continuous passage out, of iodinated substance(s). There were no conditions whatever placed on the nature of the intermediate metabolism, such as passage through special compartments in the gland, nor on the chemical identity of the end products. The analysis attempted to disclose whether the discharged iodinated products can be put into more than one class—each class being characterized by containing iodine which has a distinctly different rate of turnover in the thyroid gland. Assuming a steady state, the theory was further developed to determine the critical parameters of this system: the rate of passage of inorganic iodide into the thyroid, and, the mean rate of passage out, of iodine in each class.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c4831c7e70d2e08cc6a1bb3f4d5087 https://doi.org/10.1210/endo-62-6-758 Zobrazit plný text záznamu