Advanced laryngeal cancer T3-T4 in Sweden: a retrospective study 1986-1990. Survival and locoregional control related to treatment
| Autor: | Jan Lundgren, Claes Mercke, Richard Rylander, Richard Kuylenstierna, Anders Biörklund, Caterina Finizia, Lars Andreason, Roland Rydell, J. Lindström, Ake Geterud, Erik Holmberg |
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| Rok vydání: | 1996 |
| Předmět: |
Larynx
Adult Male medicine.medical_specialty medicine.medical_treatment Median follow-up medicine Carcinoma Humans Survival rate Laryngeal Neoplasms Aged Neoplasm Staging Retrospective Studies Sweden business.industry Cancer Retrospective cohort study Radical radiotherapy General Medicine Middle Aged medicine.disease Combined Modality Therapy Surgery Radiation therapy Survival Rate medicine.anatomical_structure Otorhinolaryngology Female business |
| Zdroj: | Acta oto-laryngologica. 116(6) |
| ISSN: | 0001-6489 |
| Popis: | Different treatment modalities for advanced laryngeal cancer are much discussed in the literature. One-hundred-and-sixty patients with T3-4, N0-3, M0-1 laryngeal cancer diagnosed in Sweden between 1986 and 1990 were retrospectively analysed. One hundred (65 T3: 35 T4) received radical radiotherapy with salvage surgery (RRSS) in case of residual or recurrent disease. Thirty-eight (11T3: 27 T4) patients received surgery with or without radiotherapy (S +/- RT). Twenty-two patients received no treatment. After a median follow up of 4.4 years, the estimated 5-year actuarial corrected survival and 3-year locoregional control were 59% and 44% for T3 RRSS and 47% and 54% for T3 S +/- RT. No significant difference between the different treatment modalities was found. The 5-year corrected survival rate and the locoregional control at 3 years between T4-RRSS (32%; 26%) and T4-S + RT (58%; 68%) groups were significantly different (p0.05 and p0.01). This might suggest that surgery with or without radiotherapy still has its place as a treatment modality for patients with advanced T4 laryngeal carcinoma. |
| Databáze: | OpenAIRE |
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