Quick, non-invasive and quantitative assessment of small fiber neuropathy in patients receiving chemotherapy
| Autor: | Olivier Huillard, Dimitri Psimaras, Thierry De Greslan, M. Sallansonnet-Froment, François Goldwasser, F.R. Ferrand, Bernard Ceccaldi, Camille Tafani, Jean-Michel Poirier, Damien Ricard, Alice Vilier, Hervé Taillia, Jean-Henri Calvet, Mehdi Saad, Jean-Marie Tigaud, Thierry Maisonobe, Sylvestre Le Moulec, Flavie Bompaire, Marie Lebouteux |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Small Fiber Neuropathy medicine.medical_treatment Urology Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Neoplasms Antineoplastic Combined Chemotherapy Protocols medicine Humans Adverse effect Survival rate Neoplasm Staging Chemotherapy business.industry Galvanic Skin Response Middle Aged medicine.disease Oxaliplatin Survival Rate Sudomotor Peripheral neuropathy Neurology Oncology Chemotherapy-induced peripheral neuropathy 030220 oncology & carcinogenesis Anesthesia Predictive value of tests Female Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Neuro-Oncology. 127:373-380 |
| ISSN: | 1573-7373 0167-594X |
| Popis: | Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common, potentially severe and dose-limiting adverse effect; however, it is poorly investigated at an early stage due to the lack of a simple assessment tool. As sweat glands are innervated by small autonomic C-fibers, sudomotor function testing has been suggested for early screening of peripheral neuropathy. This study aimed to evaluate Sudoscan, a non-invasive and quantitative method to assess sudomotor function, in the detection and follow-up of CIPN. Eighty-eight patients receiving at least two infusions of Oxaliplatin only (45.4%), Paclitaxel only (14.8%), another drug only (28.4%) or two drugs (11.4%) were enrolled in the study. At each chemotherapy infusion the accumulated dose of chemotherapy was calculated and the Total Neuropathy Score clinical version (TNSc) was carried out. Small fiber neuropathy was assessed using Sudoscan (a 3-min test). The device measures the Electrochemical Skin Conductance (ESC) of the hands and feet expressed in microSiemens (µS). For patients receiving Oxaliplatin mean hands ESC changed from 73 ± 2 to 63 ± 2 and feet ESC from 77 ± 2 to 66 ± 3 µS (p < 0.001) while TNSc changed from 2.9 ± 0.5 to 4.3 ± 0.4. Similar results were observed in patients receiving Paclitaxel or another neurotoxic chemotherapy. During the follow-up, ESC values of both hands and feet with a corresponding TNSc < 2 were 70 ± 2 and 73 ± 2 µS respectively while they were 59 ± 1.4 and 64 ± 1.5 µS with a corresponding TNSc ≥ 6 (p < 0.0001 and p = 0.0003 respectively). This preliminary study suggests that small fiber neuropathy could be screened and followed using Sudoscan in patients receiving chemotherapy. |
| Databáze: | OpenAIRE |
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