Effects of Preinjury and Postinjury Exposure to Caffeine in a Rat Model of Traumatic Brain Injury
| Autor: | Theresa A. Lusardi, Hoda Gebril, Nikki K. Lytle, Detlev Boison |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Physiology Traumatic brain injury business.industry Public Health Environmental and Occupational Health Apnea Original Articles medicine.disease Adenosine receptor antagonist Biochemistry Adenosine chemistry.chemical_compound Bolus (medicine) chemistry Anesthesia medicine Respiratory function Brainstem medicine.symptom Caffeine business Food Science medicine.drug |
| Zdroj: | J Caffeine Adenosine Res |
| ISSN: | 2573-3400 2573-3397 |
| DOI: | 10.1089/caff.2019.0012 |
| Popis: | Background: Lethal apnea is a significant cause of acute mortality following a severe traumatic brain injury (TBI). TBI is associated with a surge of adenosine, which also suppresses respiratory function in the brainstem. Methods and Materials: This study examined the acute and chronic effects of caffeine, an adenosine receptor antagonist, on acute mortality and morbidity after fluid percussion injury. Results: We demonstrate that, regardless of preinjury caffeine exposure, an acute bolus of caffeine given immediately following the injury dosedependently prevented lethal apnea and has no detrimental effects on motor performance following sublethal injuries. Finally, we demonstrate that chronic caffeine treatment after injury, but not caffeine withdrawal, impairs recovery of motor function. Conclusions: Preexposure of the injured brain to caffeine does not have a major impact on acute and delayed outcome parameters; more importantly, a single acute dose of caffeine after the injury can prevent lethal apnea regardless of chronic caffeine preexposure. |
| Databáze: | OpenAIRE |
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