Cell division and apoptosis in the adult neural stem cell niche are differentially affected in transthyretin null mice
| Autor: | Zahra Hassani, Barbara A. Demeneix, Samantha J. Richardson, Gregory F. Lemkine, Gladys Alfama |
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| Přispěvatelé: | Department of Epidemiology and Public Health, Imperial College Norfolk Place, Evolution des régulations endocriniennes (ERE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
MESH: Cell Differentiation
medicine.medical_specialty Programmed cell death endocrine system Cell division Tyrosine 3-Monooxygenase MESH: Neurons Subventricular zone Apoptosis MESH: Stem Cells Biology MESH: Mice Knockout Cerebral Ventricles 03 medical and health sciences Mice 0302 clinical medicine Internal medicine MESH: Prealbumin medicine Animals Prealbumin MESH: Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Progenitor cell MESH: Tyrosine 3-Monooxygenase MESH: Mice 030304 developmental biology Mice Knockout Neurons 0303 health sciences General Neuroscience Stem Cells MESH: Apoptosis nutritional and metabolic diseases Cell Differentiation Neural stem cell Transthyretin medicine.anatomical_structure Endocrinology nervous system biology.protein MESH: Cell Division Choroid plexus MESH: Cerebral Ventricles Stem cell 030217 neurology & neurosurgery Cell Division |
| Zdroj: | Neuroscience Letters Neuroscience Letters, Elsevier, 2007, 421 (3), pp.234-8. ⟨10.1016/j.neulet.2007.05.040⟩ |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2007.05.040⟩ |
| Popis: | Thyroid hormones (THs) are fundamental in regulation of growth and development, particularly of the brain. THs are required for full proliferative activity of neural stem cells in the subventricular zone (SVZ) of adult mouse brains, and also affect the normal fate of progenitor cells: apoptosis. Transthyretin (TTR) is a TH distributor protein in the blood and cerebrospinal fluid. TTR secretion by the choroid plexus is involved in transport of THs from blood into cerebrospinal fluid. We investigated the regulation of neural stem cell cycle in the SVZ of adult TTR null mice. Markers for neural stem cell mitosis that are reduced during hypothyroidism, did not differ between genotypes. However, in TTR null mice the level of apoptosis, the fate of most progenitor cells, was as low as that in brains of hypothyroid wildtype mice. Thus, lack of TTR results in reduced availability of TH to progenitor cells in the SVZ. We show that proliferation and apoptosis in the SVZ neural stem cell niche are differentially affected by the lack of TTR synthesis. |
| Databáze: | OpenAIRE |
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