Extensive intracranial haemorrhage as a complication of acute lymphoblastic leukaemia with hyperleukocytosis
Autor: | Jen Chun Foo, Limin Li, Tsiao Yi Yap, Wei Kang Lim, Choong Yi Fong |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Leukocytosis medicine.medical_treatment Grey matter 03 medical and health sciences 0302 clinical medicine Immunophenotyping Physiology (medical) medicine Humans Child Chemotherapy medicine.diagnostic_test Upper motor neuron business.industry Magnetic resonance imaging General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Magnetic Resonance Imaging medicine.anatomical_structure Hemiparesis Neurology 030220 oncology & carcinogenesis Surgery Female Neurology (clinical) Radiology Brainstem medicine.symptom Complication business Intracranial Hemorrhages 030217 neurology & neurosurgery |
Zdroj: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 64 |
ISSN: | 1532-2653 |
Popis: | We report a rare case of distinctive extensive punctate intracranial haemorrhage associated with acute lymphoblastic leukaemia with hyperleukocytosis. A 7-year-old girl presented with hyperleukocytosis (white cell count 788.7 × 109/L; 94% peripheral blasts) and laboratory tumour lysis syndrome. The diagnosis of T-cell acute lymphoblastic leukaemia was established and confirmed by immunophenotyping of peripheral blood and chemotherapy was commenced promptly. On day 3 of treatment, she developed progressive encephalopathy, left sided hemiparesis with left 6th and upper motor neuron 7th cranial nerve palsy. Brain MRI scan showed extensive punctate haemorrhages with perilesional oedema over the frontal, parietal, occipital, temporal, brainstem and cerebellar regions. The lesions were predominantly over the juxtacortical grey matter. She made a full neurological recovery after 3 months. Our report widens the neuroradiological features of intracranial haemorrhage associated with hyperleukocytosis and highlights the importance of prompt chemotherapy in these patients. |
Databáze: | OpenAIRE |
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