Burn-Induced Local and Systemic Immune Response: Systematic Review and Meta-Analysis of Animal Studies
| Autor: | Patrick P.G. Mulder, Hans J.P.M. Koenen, Marcel Vlig, Irma Joosten, Rob B.M. de Vries, Bouke K.H.L. Boekema |
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| Rok vydání: | 2022 |
| Předmět: |
Neutrophils
Macrophages Cell Biology Dermatology Biochemistry Rats Anti-Bacterial Agents Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] All institutes and research themes of the Radboud University Medical Center Animals Inflammation Mediators Burns Molecular Biology Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5] |
| Zdroj: | Journal of Investigative Dermatology, 142, 3093-3109.e15 Journal of Investigative Dermatology, 142, 11, pp. 3093-3109.e15 |
| ISSN: | 0022-202X |
| Popis: | Because burn injuries are often followed by a derailed immune response and excessive inflammation, a thorough understanding of the occurring reactions is key to preventing secondary complications. This systematic review, which includes 247 animal studies, shows the postburn response of 14 different immune cell types involved in immediate and long-term effects in both wound tissue and circulation. Peripheral blood neutrophil and monocyte numbers increased directly after burns, whereas thrombocyte numbers increased near the end of the first week. However, lymphocyte numbers were decreased for at least 2 weeks. In burn wound tissue, neutrophil and macrophage numbers accumulated during the first 3 weeks. Burns also altered cellular functions because we found an increased migratory potential of leukocytes, impaired antibacterial activity of neutrophils, and enhanced inflammatory mediator production by macrophages. Neutrophil surges were positively associated with burn size and were highest in rats. Altogether, this comprehensive overview of the temporal immune cell dynamics shows that unlike normal wound healing, burn injury induces a long-lasting inflammatory response. It provides a fundamental research basis to improve experimental set-ups, burn care, and outcomes. |
| Databáze: | OpenAIRE |
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