IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population
| Autor: | D Y Yang, S X Dong, H M Feng, Y T Li, B L Xu, L Zi, J Qi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Gastroenterology Polymorphism Single Nucleotide law.invention Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Asian People law Risk Factors Stomach Neoplasms Internal medicine Genetic variation Genotype Genetics medicine Humans Genetic Predisposition to Disease Molecular Biology Polymerase chain reaction Genetic Association Studies Aged biology Helicobacter pylori business.industry Interleukin-17 Interleukin General Medicine Middle Aged biology.organism_classification 030104 developmental biology 030220 oncology & carcinogenesis Female Gene polymorphism Interleukin 17 Restriction fragment length polymorphism business |
| Zdroj: | Genetics and molecular research : GMR. 15(2) |
| ISSN: | 1676-5680 |
| Popis: | The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People's Hospital between March 2013 and March 2015. The IL-17 rs2275913 gene polymorphism was identified by polymerase chain reaction and restriction fragment length polymorphism. When compared with control subjects, gastric cancer patients were older in age (OR = 3.89, 95%CI = 2.55-5.95), male (OR = 2.08, 95%CI = 1.39-3.10), had a habit of alcohol consumption (OR = 1.71, 95%CI = 1.15-2.55), and were more likely to be infected with Helicobacter pylori (OR = 2.76, 95%CI = 1.83-4.16). We observed that the AA genotype of the IL-17 rs2275913 polymorphism resulted in a 2.32-fold risk of gastric cancer compared to the GG genotype (OR = 2.32, 95%CI = 1.20-4.54; P = 0.01). The AG combined with AA genotype of the IL-17 rs2275913 polymorphism had more risk of developing gastric cancer than the GG genotype (OR = 1.50, 95%CI = 1.01-2.23; P = 0.04). Moreover, the AA genotype of the IL-17 rs2275913 polymorphism was correlated with a higher risk of developing gastric cancer than the GG and AG genotypes combined (OR = 2.01, 95%CI = 1.08-3.79; P = 0.02). In conclusion, the results of our study suggest that the IL-17 rs2275913 polymorphism could contribute to the risk of gastric cancer. |
| Databáze: | OpenAIRE |
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