Factors associated with 36-month loss to follow-up and mortality outcomes among HIV-infected adults on antiretroviral therapy in Central Kenya
| Autor: | Angela McLigeyo, Jonathan Mwangi, Kenneth Masamaro, Kevin Owuor, Evelyne Nganga, Paul Wekesa |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty HIV Infections Loss to follow-up 030312 virology Logistic regression Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine Epidemiology Risk of mortality Humans Medicine 030212 general & internal medicine Mortality Retrospective Studies 0303 health sciences Marital Status business.industry lcsh:Public aspects of medicine Age Factors Public Health Environmental and Occupational Health HIV lcsh:RA1-1270 Odds ratio Middle Aged Kenya Confidence interval Antiretroviral therapy Treatment Outcome Anti-Retroviral Agents Marital status Female Lost to Follow-Up Biostatistics business Body mass index Research Article |
| Zdroj: | BMC Public Health, Vol 20, Iss 1, Pp 1-11 (2020) BMC Public Health |
| DOI: | 10.21203/rs.2.18191/v1 |
| Popis: | Background The scale-up of HIV treatment programs has resulted in a reduction in HIV-related morbidity and mortality. However, retention of patients in these programs remains a challenge in sub-Saharan Africa. Understanding factors associated with loss to follow-up (LTFU) and mortality outcomes is therefore important to inform targeted program interventions. Methods A retrospective multi-cohort analysis of 23,890 adult patients on ART over 36 months of follow-up in Kenya was done. Multivariate logistic regression analysis was done to assess for factors associated with LTFU and mortality at 6, 12, 24, and 36 months of follow-up. Results Majority, 67.7%, were female. At 36 months, 27.2% were LTFU and 13.5% had died. Factors associated with mortality at 36 months included older age (51 years and above) using 20–35 years as reference [(adjusted odds ratio [aOR], 1.51, 95% confidence interval (CI) 1.23–1.86, p p p 2 using 18.5–24.9 kg/m2 as reference (aOR = 1.79, 95% CI 1.52–2.11, p p p p p 2 using normal BMI as reference (aOR, 1.68, 95% CI 1.39–2.02, p Conclusions Factors associated with LTFU and mortality were generally similar over time. Implementation of programs in similar settings should be tailored to gender, age profiles, nutritional, and, marital status of patients to address LTFU. In addition, programs should focus on the care of older patients to reduce the risk of mortality. |
| Databáze: | OpenAIRE |
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