Triglyceride to high-density lipoprotein cholesterol ratio as a predictor of long-term mortality in patients with coronary artery disease after undergoing percutaneous coronary intervention: a retrospective cohort study
Autor: | Kai Wang, Lei Fan, Junnan Tang, Xin-Ya Dai, Xiao-Ting Yue, Meng-Die Cheng, Qian-Qian Guo, Ying-Ying Zheng, Jian-Chao Zhang, Li-Zhu Jiang, Xu-Ming Yang, Yan Bai, Zhi-Yu Liu, Jin-Ying Zhang, Ru-Jie Zheng, Zeng-Lei Zhang, Feng-Hua Song |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Coronary Disease Kaplan-Meier Estimate 030204 cardiovascular system & hematology Coronary artery disease Percutaneous coronary intervention chemistry.chemical_compound 0302 clinical medicine Endocrinology High-density lipoprotein Risk Factors 030212 general & internal medicine lcsh:RC620-627 Middle Aged Triglyceride to high-density lipoprotein cholesterol ratio All-cause mortality lcsh:Nutritional diseases. Deficiency diseases Treatment Outcome Cardiology Female medicine.medical_specialty 03 medical and health sciences Internal medicine medicine Humans Triglycerides Aged Proportional Hazards Models Retrospective Studies Heart Failure Proportional hazards model business.industry Research Cholesterol HDL Biochemistry (medical) Retrospective cohort study Cholesterol LDL medicine.disease chemistry Heart failure Multivariate Analysis Conventional PCI Metabolic syndrome business Biomarkers |
Zdroj: | Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-8 (2019) Lipids in Health and Disease |
Popis: | Background It has been confirmed that the triglyceride to high-density lipoprotein cholesterol ratio (THR) is associated with insulin resistance and metabolic syndrome. However, to the best of our knowledge, only a few studies with small sample sizes have investigated the relationship between THR and coronary artery disease (CAD). Therefore, we aimed to assess the correlation between the THR and long-term mortality in patients with CAD after undergoing percutaneous coronary intervention (PCI) in our study that enrolled a large number of patients. Methods A total of 3269 post-PCI patients with CAD were enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The mean follow-up time was 37.59 ± 22.24 months. Patients were divided into two groups according to their THR value: the lower group (THR n = 1232) and the higher group (THR ≥ 2.84, n = 2037). The primary endpoint was long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints were major adverse cardiac events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs). Results In our study, ACM occurred in 124 patients: 30 (2.4%) in the lower group and 94 (4.6%) in the higher group (P = 0.002). MACEs occurred in 362 patients: 111 (9.0%) in the lower group and 251 (12.3%) in the higher group (P = 0.003). The number of MACCEs was 482: 152 (12.3%) in the lower group and 320 (15.7%) in the higher group (P = 0.008). Heart failure occurred in 514 patients: 89 (7.2%) in the lower group and 425 (20.9%) in the higher group (P P = 0.044) and the occurrence of heart failure (log-rank, P P = 0.004) and heart failure (adjusted HR = 1.700 [1.347–2.147], P Conclusions An increased THR is an independent predictor of long-term ACM and heart failure in post-PCI patients with CAD. |
Databáze: | OpenAIRE |
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