Triglyceride to high-density lipoprotein cholesterol ratio as a predictor of long-term mortality in patients with coronary artery disease after undergoing percutaneous coronary intervention: a retrospective cohort study

Autor: Kai Wang, Lei Fan, Junnan Tang, Xin-Ya Dai, Xiao-Ting Yue, Meng-Die Cheng, Qian-Qian Guo, Ying-Ying Zheng, Jian-Chao Zhang, Li-Zhu Jiang, Xu-Ming Yang, Yan Bai, Zhi-Yu Liu, Jin-Ying Zhang, Ru-Jie Zheng, Zeng-Lei Zhang, Feng-Hua Song
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Coronary Disease
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Coronary artery disease
Percutaneous coronary intervention
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
High-density lipoprotein
Risk Factors
030212 general & internal medicine
lcsh:RC620-627
Middle Aged
Triglyceride to high-density lipoprotein cholesterol ratio
All-cause mortality
lcsh:Nutritional diseases. Deficiency diseases
Treatment Outcome
Cardiology
Female
medicine.medical_specialty
03 medical and health sciences
Internal medicine
medicine
Humans
Triglycerides
Aged
Proportional Hazards Models
Retrospective Studies
Heart Failure
Proportional hazards model
business.industry
Research
Cholesterol
HDL
Biochemistry (medical)
Retrospective cohort study
Cholesterol
LDL
medicine.disease
chemistry
Heart failure
Multivariate Analysis
Conventional PCI
Metabolic syndrome
business
Biomarkers
Zdroj: Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-8 (2019)
Lipids in Health and Disease
Popis: Background It has been confirmed that the triglyceride to high-density lipoprotein cholesterol ratio (THR) is associated with insulin resistance and metabolic syndrome. However, to the best of our knowledge, only a few studies with small sample sizes have investigated the relationship between THR and coronary artery disease (CAD). Therefore, we aimed to assess the correlation between the THR and long-term mortality in patients with CAD after undergoing percutaneous coronary intervention (PCI) in our study that enrolled a large number of patients. Methods A total of 3269 post-PCI patients with CAD were enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The mean follow-up time was 37.59 ± 22.24 months. Patients were divided into two groups according to their THR value: the lower group (THR n = 1232) and the higher group (THR ≥ 2.84, n = 2037). The primary endpoint was long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints were major adverse cardiac events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs). Results In our study, ACM occurred in 124 patients: 30 (2.4%) in the lower group and 94 (4.6%) in the higher group (P = 0.002). MACEs occurred in 362 patients: 111 (9.0%) in the lower group and 251 (12.3%) in the higher group (P = 0.003). The number of MACCEs was 482: 152 (12.3%) in the lower group and 320 (15.7%) in the higher group (P = 0.008). Heart failure occurred in 514 patients: 89 (7.2%) in the lower group and 425 (20.9%) in the higher group (P P = 0.044) and the occurrence of heart failure (log-rank, P P = 0.004) and heart failure (adjusted HR = 1.700 [1.347–2.147], P Conclusions An increased THR is an independent predictor of long-term ACM and heart failure in post-PCI patients with CAD.
Databáze: OpenAIRE
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