Metabolic pathways of bile acid synthesis
| Autor: | Paul M. Hyde, William H. Elliott |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
Taurine Glycine Hydroxylation Intestinal absorption Feedback Mixed Function Oxygenases Bile Acids and Salts chemistry.chemical_compound Internal medicine CYP27A1 medicine Animals Humans Cholestanes Cholesterol business.industry Hydroxysteroid Dehydrogenases General Medicine Metabolism Ketones Sterols Metabolic pathway Endocrinology Intestinal Absorption Liver chemistry Oxidoreductases CYP8B1 business NADP Liver Circulation |
| Zdroj: | The American Journal of Medicine. 51:568-579 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(71)90281-6 |
| Popis: | The major pathway for the metabolism and excretion of cholesterol in mammals is the formation of acidic steroids in the liver. Although in principle the theme is the same, there are variations that make different species quite distinctive. Man synthesizes only two primary bile acids and conjugates each of these with either glycine or taurine to yield primary bile salts. The rat and mouse, which have served as the prime experimental model for man, can produce several additional bile acids. Although the end products of cholesterol metabolism are not the same, certain generalizations seem valid at present. In particular, considerable evidence has been amassed to implicate the 7α-hydroxylation of cholesterol as the initial rate-controlling step in bile acid biosynthesis. The sequence of events following this step and possible alternate pathways are less well delineated. Because of the number of enzymes committed to the formation of bile acids from cholesterol, it is possible that genetic or acquired defects in their synthesis may result in clinically apparent liver disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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