A New Crystalline Ketoprofen Sodium Salt: Solid-State Characterization, Solubility, and Stability
| Autor: | Magali Benjamim Araújo, Thulio Wliandon Lemos Barbosa, Rudy Bonfilio, Bruno Arantes Borges, Homero de Oliveira Junior, Ataislaine Batista, Maria Teresa Leite Braga |
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| Přispěvatelé: | Federal University of Alfenas (UNIFAL-MG), Universidade Estadual Paulista (UNESP) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Thermogravimetric analysis
Materials science Aqueous solution Absorption of water Calorimetry Differential Scanning Sodium Pharmaceutical Science Water Fourier transform infrared spectroscopy Dosage form Differential scanning calorimetry X-Ray Diffraction Solid-state characterization Solubility Ketoprofen X-ray powder diffraction Spectroscopy Fourier Transform Infrared Thermal analysis Absorption (chemistry) Powders Ketoprofen sodium Stability Nuclear chemistry |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2022-04-28T19:47:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Ketoprofen (KTP) is an Active Pharmaceutical Ingredient (API) that has low solubility in aqueous solvents. The use of KTP salts has attracted attention due to its improvements in terms of solubility, tolerability, higher rate and extent of absorption, and faster onset of the therapeutic effect. In this work, a crystalline KTP sodium salt (coded as KTP-Na) was successfully obtained and widely characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), solubility and accelerated stability studies. XRD results showed that KTP-Na is not yet reported in the literature. Moreover, FTIR, DSC and TGA were useful for differentiation of KTP-Na from the KTP commercialized form (coded as KTP-R1). The solubility of KTP-Na in water was about 80 times greater than the KTP-R1. However, KTP-Na showed lower physical stability in storage conditions at 40 ± 2°C/ 75% ± 5% RH when compared to KTP-R1, which was shown to be related to a high hygroscopicity of KTP-Na. Therefore, due to its higher solubility, KTP-Na may be a viable alternative for use in solid dosage forms. However, the presence of moisture must be strictly controlled to avoid water absorption and consequent amorphization. Faculty of Pharmaceutical Sciences Federal University of Alfenas (UNIFAL-MG) Institute of Chemistry Federal University of Alfenas (UNIFAL-MG) Faculty of Pharmaceutical Sciences São Paulo State University (UNESP-SP) Faculty of Pharmaceutical Sciences São Paulo State University (UNESP-SP) |
| Databáze: | OpenAIRE |
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